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New Trends in Bioactive Lipids Research in Health and Disease...
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New Trends in Bioactive Lipids Research in Health and Disease Volume II

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 7135

Special Issue Editors

Dr. Luís Miguel Rodriguez-Alcalá

E-Mail Website
Guest Editor
Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Porto, Portugal
Interests: lipidomics; functional foods; bioactive lipids; food safety
Special Issues, Collections and Topics in MDPI journals
Dr. Lígia Pimentel

E-Mail Website
Guest Editor
Centre of Biotechnology and Fine Chemistry, Universidade Católica Portuguesa, Lisbon, Portugal
Interests: lipid isolation; bioactivity; food science; dairy products; functional foods; Mass Spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Susana Vidigal

E-Mail Website
Guest Editor
Centre of Biotechnology and Fine Chemistry, Universidade Católica Portuguesa, Lisbon, Portugal
Interests: low pressure chromatography; lipidomics; terpenes; phytochemicals; food quality
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipidomics, a branch of omics science, has gained relevance due to recent discoveries linking lipids to biological processes such as the maintenance of homeostasis. Besides being involved in the origin of obesity and cardiovascular diseases, lipids can influence the regulation of inflammation and the immune system, neuronal function or even the metabolism of tumor energy.

Lipids are a complex family both at a structural level and in terms of physical-chemical properties; therefore the development of methods of isolation and analysis by means of mass spectrometry and/or combinations of different chromatographic techniques has been shown to be essential.

Food research is directly linked to lipidomics because it is focused not only on the identification of sources of bioactive lipids but also on the determination of biological properties and their mechanisms of action.

The success of the first volume of this Special Issue "New Trends in Bioactive Lipids Research in Health and Disease" inspired us to edit a new volume. Thus, we encourage researchers from the lipidomics field to submit their research. We welcome the submission of original research articles and reviews focused on the development of methods of isolation and analysis, the determination of biological properties and their mechanisms of action along with ways to include them in functional foods. We also welcome papers on applications in health and disease.

Dr. Luís Miguel Rodriguez - Alcalá
Dr. Lígia Pimentel
Dr. Susana Vidigal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipids
  • bioactivity
  • foods

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Published Papers (3 papers)

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Research

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12 pages, 2719 KiB  
Communication
Online Extraction Followed by LC–MS/MS Analysis of Lipids in Natural Samples: A Proof-of-Concept Profiling Lecithin in Seeds
by João V. B. Borsatto, Edvaldo V. S. Maciel, Alejandro Cifuentes and Fernando M. Lanças
Foods 2023, 12(2), 281; https://doi.org/10.3390/foods12020281 - 7 Jan 2023
Cited by 6 | Viewed by 2131
Abstract
Sample preparation is usually a complex and time-consuming procedure, which can directly affect the quality of the analysis. Recent efforts have been made to establish analytical methods involving minimal sample preparation, automatized and performed online with the analytical techniques. Online Extraction coupled with [...] Read more.
Sample preparation is usually a complex and time-consuming procedure, which can directly affect the quality of the analysis. Recent efforts have been made to establish analytical methods involving minimal sample preparation, automatized and performed online with the analytical techniques. Online Extraction coupled with Liquid Chromatography–Mass Spectrometry (OLE–LC–MS) allows a fully connected extraction, separation, and analysis system. In this work, the lecithin profile was investigated in commercial sunflower, almonds, peanuts, and pistachio seeds to demonstrate that the concept of extraction, followed by the online analysis of the extract, could be applied to analyze this class of analytes in such complex solid matrices without a prior off-line solvent extraction step. The extraction phase gradient method was optimized. Two different analytical columns were explored, one being a conventional C18 (50 × 2.1 mm, 1.7 µm SPP) and the other a novel self-packed SIGO-C18ec (100 × 0.5, 5 µm FPP), which resulted in better separation. The analysis repeatability was investigated, and suggestions to improve it were pointed out. A characteristic ion with a m/z of 184, related to lysophosphatidylcholine structure, was used to identify the lecithin compounds. The temperature effect on the chromatograms was also explored. In short, it was found that the OLE–LC–MS approach is suitable for the analysis of lecithin compounds in seeds, being a promising alternative for lipidomics approaches in the near future. Full article
(This article belongs to the Special Issue New Trends in Bioactive Lipids Research in Health and Disease Volume II)
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18 pages, 1740 KiB  
Article
Suitability of Solvent-Assisted Extraction for Recovery of Lipophilic Phytochemicals in Sugarcane Straw and Bagasse
by Francisca S. Teixeira, Lígia L. Pimentel, Susana S. M. P. Vidigal, Paula T. Costa, Manuela E. Pintado and Luís M. Rodríguez-Alcalá
Foods 2022, 11(17), 2661; https://doi.org/10.3390/foods11172661 - 1 Sep 2022
Cited by 3 | Viewed by 2261
Abstract
Sugarcane is primarily harvested to meet up to 80% of global sugar demand. Recently, lipids recovered from their biomass (straw and bagasse) have attracted much attention due to their possible utilisation in biofuel production but also by the presence of health-promoting compounds as [...] Read more.
Sugarcane is primarily harvested to meet up to 80% of global sugar demand. Recently, lipids recovered from their biomass (straw and bagasse) have attracted much attention due to their possible utilisation in biofuel production but also by the presence of health-promoting compounds as phytosterols (i.e., improvement of cardiovascular function) or 1-octacosanol (i.e., anti-obesity). Although this fraction is commonly obtained through solid–liquid isolation, there is scarce information about how different solvents affect the composition of the extracts. This research work aimed to study whether, in sugarcane straw and bagasse samples, Soxtec extraction with widely used dichloromethane (DCM) would be suitable to recover most of the lipid classes when compared to other available solvents such as food grade ethanol (EtOH) or solvents without regulation restrictions for food and drug applications (i.e., acetone and ethyl acetate). The obtained results allow concluding that sugarcane waxes from straw and bagasse are complex lipid mixtures of polar and non-polar compounds. According to the extraction yield, the best results were obtained with ethanol (5.12 ± 0.30% and 1.97 ± 0.31%) for both straw and bagasse, respectively. The extractant greatly influenced the lipid composition of the obtained product. Thus, DCM enriched the isolates in glycerolipids (mono-, di- and triglycerides), free fatty acids, fatty alcohols, fatty aldehydes, phytosterols and hydrocarbons. On the other hand, EtOH resulted in polar isolates rich in glycolipids. Therefore, depending on the application and objectives of future research studies, the solvent to recover such lipids needs to be carefully selected. Full article
(This article belongs to the Special Issue New Trends in Bioactive Lipids Research in Health and Disease Volume II)
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Review

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31 pages, 494 KiB  
Review
Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models
by Francisca S. Teixeira, Paula T. Costa, Ana M. S. Soares, Ana Luiza Fontes, Manuela E. Pintado, Susana S. M. P. Vidigal, Lígia L. Pimentel and Luís M. Rodríguez-Alcalá
Foods 2023, 12(13), 2576; https://doi.org/10.3390/foods12132576 - 1 Jul 2023
Cited by 1 | Viewed by 2189
Abstract
Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids. In this state-of-the-art review, we discuss these lipids, and their activity against obesity and mental or neurological [...] Read more.
Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids. In this state-of-the-art review, we discuss these lipids, and their activity against obesity and mental or neurological disorders, with a focus on their proposed cellular targets and the ways in which they produce their beneficial effects. Furthermore, this available information is compared with that provided by in silico Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) models in order to understand the usefulness of these tools for the discovery of new bioactive compounds. Accordingly, it was possible to highlight how these lipids interact with various cellular targets related to the molecule transportation and absorption (e.g., α-tocopherol transfer protein for α-Tocopherol, ATP-binding cassette ABC transporters or Apolipoprotein E for sphingomyelins and phospholipids) or other processes, such as the regulation of gene expression (involving Sterol Regulatory Element-Binding Proteins for ergosterol or Peroxisome Proliferator-Activated Receptors in the case of policosanol) and inflammation (the regulation of interleukins by sodium butyrate). When comparing the literature with in silico Quantitative Structure–Activity Relationship (QSAR) models, it was observed that although they are useful for selecting bioactive molecules when compared in batch, the information they provide does not coincide when assessed individually. Our review highlights the importance of considering a broad range of lipids as potential bioactives and the need for accurate prediction of ADMET parameters in the discovery of new biomolecules. The information presented here provides a useful resource for researchers interested in developing new strategies for the treatment of obesity and mental or neurological disorders. Full article
(This article belongs to the Special Issue New Trends in Bioactive Lipids Research in Health and Disease Volume II)
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