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Foods
Special Issues
New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome
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New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 8072

Special Issue Editors

Dr. Gwang-Woong Go

E-Mail Website
Guest Editor
Department of Food and Nutrition, Hanyang University, Seoul 04763, Korea
Interests: nutrigenomics; obesity; bioactive compounds; lipid metabolism; metabolic syndromes
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Wooki Kim

E-Mail Website
Co-Guest Editor
Department of Food Science and Biotechnology, Kyung Hee University, Seoul, Republic of Korea
Interests: bioactive compounds; immunology; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of chronic metabolic diseases is steadily growing worldwide, causing an increased burden for patients due to the deterioration of individual quality of life and the amassing of enormous socioeconomic costs. When addressing these issues, research on verifying the physiological activity of nutraceuticals containing bioactive compounds shows the possibility of preventive and therapeutic treatment. Moreover, the research on bioactive compounds expands into cutting-edge science by introducing state-of-the-art technologies. This Special Issue invites papers that research the recent development of nutraceuticals related to chronic metabolic diseases, obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, inflammation, and dyslipidemia. This Special Issue aspires to provide the most trustworthy knowledge on the latest nutraceuticals to food scientists, nutritionists, and specialists to discover medicines. It is hoped that leading scientists in these fields will be able to contribute to yielding original results within this field.

Dr. Gwang-Woong Go 
Prof. Dr. Wooki Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceutical
  • chronic metabolic diseases
  • nutrigenomics
  • non-alcoholic fatty liver disease
  • obesity
  • type 2 diabetes mellitus
  • inflammation
  • dyslipidemia

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Published Papers (4 papers)

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Research

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12 pages, 2376 KiB  
Article
The Herbal Blend of Sphaeranthus indicus and Garcinia mangostana Reduces Adiposity in High-Fat Diet Obese Mice
by Sumin Kang, Hayoon Kim, Chaeyoung Bang, Jung Hyeon Park and Gwang-woong Go
Foods 2024, 13(18), 3013; https://doi.org/10.3390/foods13183013 - 23 Sep 2024
Viewed by 1065
Abstract
Obesity is swiftly becoming a global epidemic, leading to numerous metabolic disorders and substantial socio-economic burdens. Investigating natural bioactive compounds is crucial to support the use of traditional anti-obesity medications while mitigating the adverse effects. This study posited that a combination of Sphaeranthus [...] Read more.
Obesity is swiftly becoming a global epidemic, leading to numerous metabolic disorders and substantial socio-economic burdens. Investigating natural bioactive compounds is crucial to support the use of traditional anti-obesity medications while mitigating the adverse effects. This study posited that a combination of Sphaeranthus indicus and Garcinia mangostana (Meratrim) could prevent fat accumulation in obese mice. We used 4-week-old C57BL/6NTac mice, dividing them into six groups: (1) normal diet (ND); (2) high-fat diet (HFD, 45% kcal from fat); (3–5) Meratrim150, Meratrim300, and Meratrim450 (HFD with 150, 300, and 450 mg/kg bw of Meratrim); and (6) Metformin (HFD with 150 mg/kg bw of metformin). Meratrim was administered orally each day for 20 weeks. The group receiving 450 mg/kg of Meratrim showed a significant reduction in body weight and fat mass without changes in food consumption. The Meratrim450 group had markedly lower triglyceride levels in both serum and liver. Importantly, Meratrim-supplemented mice improved lipid homeostasis by inhibiting hepatic de novo lipogenesis and activating energy catabolic pathways such as non-shivering thermogenesis in brown adipose tissue. Our results suggest that the herbal mixture of Sphaeranthus indicus and Garcinia mangostana (Meratrim) is a promising natural anti-obesity agent, owing to its efficacy in reducing body fat and enhancing lipid homeostasis. Full article
(This article belongs to the Special Issue New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome)
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20 pages, 15951 KiB  
Article
L-Theanine Ameliorates Obesity-Related Complications Induced by High-Fat Diet in Mice: Insights from Transcriptomics and Metabolomics
by Zhaofeng Du, Guohuo Wu, Huijun Cheng, Tingting Han, Daxiang Li and Zhongwen Xie
Foods 2024, 13(18), 2977; https://doi.org/10.3390/foods13182977 - 19 Sep 2024
Viewed by 1126
Abstract
Obesity is a major public health concern globally. Plant-based ingredients have been proposed as alternative treatments for obesity. L-Theanine (THE), a unique nutraceutical component of tea, is known for its neuroprotective and cognitive benefits. However, there are few reports on THE’s effects and [...] Read more.
Obesity is a major public health concern globally. Plant-based ingredients have been proposed as alternative treatments for obesity. L-Theanine (THE), a unique nutraceutical component of tea, is known for its neuroprotective and cognitive benefits. However, there are few reports on THE’s effects and mechanisms in improving obesity and its complications. In this study, the alleviating effects and potential mechanisms of THE on obesity-related complications (ORCs) induced by a high-fat diet(HFD) in mice were explored by performing biochemical, hepatic transcriptomics, and plasma metabolomics analyses. The results indicated THE (900 mg/kg of body weight) was effective in mitigating ORCs by decreasing body weight gain and fat deposition, improving glycolipid metabolism disorders, inflammation dysregulation, and alleviating fatty liver formation due to long-term HFD. The hepatic transcriptomics data suggested that THE intervention suppresses the lipid metabolism and inflammation pathways in HFD-fed mice, thereby inhibiting hepatic steatosis and inflammation. Moreover, plasma metabolomics analysis revealed that THE exhibited positive effects on the homeostasis of plasma metabolite balance, such as phosphatidylcholine (PC(14:0/18:1)), phosphatidylethanolamine (Lyso-PE(14:0)), phosphatidic acid (PA(16:0e/18:0)), stigmasterol, and deoxycholic acid glycine conjugate. These metabolites were strongly correlated with ORC-related indicators. Our results indicated that THE, as a functional food additive, possesses potential for ORC alleviation. However, the exact molecular mechanism of how THE alleviates ORCs needs to be investigated in the future. Full article
(This article belongs to the Special Issue New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome)
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16 pages, 7370 KiB  
Article
Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model
by Min Woo Kim, Yu-Jin Ham, Hyun-Bok Kim, Ji young Lee, Jung-Dae Lim and Hyun-Tai Lee
Foods 2023, 12(19), 3613; https://doi.org/10.3390/foods12193613 - 28 Sep 2023
Viewed by 1398
Abstract
Recently, “mature” silkworms (MS) of Bombix mori have been considered a potential nutraceutical, with a number of health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects have been reported for SMSP. In the present study, anti-obesity effects of [...] Read more.
Recently, “mature” silkworms (MS) of Bombix mori have been considered a potential nutraceutical, with a number of health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects have been reported for SMSP. In the present study, anti-obesity effects of SMSP were investigated in adult mice in vivo, aged 12 weeks at the onset of SMSP treatment, fed a normal diet (ND) and a high-fat diet (HFD), respectively, for 12 weeks. SMSP significantly suppressed body weight gain, intra-abdominal adipose tissue, and food efficiency in both ND-fed and HFD-fed adult mice. In addition, SMSP significantly decreased food intake and liver weight in HFD-fed mice, indicating that SMSP suppressed appetite and simultaneously reduced the conversion of feed into body weight in HFD-fed mice. SMSP also significantly lowered the serum levels of glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, asparagine transaminase, alanine transaminase, and alkaline phosphatase. However, SMSP had no significant effect on the weights of the kidney, spleen, or thymus or the serum levels of blood urea nitrogen and creatinine. Taken together, the above results suggest that SMSP has potent anti-obesity effects and is safe for long-term use as a potential therapeutic and/or nutraceutical in both obese patients and non-obese individuals. Full article
(This article belongs to the Special Issue New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome)
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Review

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17 pages, 3376 KiB  
Review
Effect of the Combination of Hibiscus sabdariffa in Combination with Other Plant Extracts in the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis
by Ana María García-Muñoz, Ana I. García-Guillén, Desirée Victoria-Montesinos, María Salud Abellán-Ruiz, Begoña Alburquerque-González and Fernando Cánovas
Foods 2023, 12(11), 2269; https://doi.org/10.3390/foods12112269 - 5 Jun 2023
Cited by 5 | Viewed by 3810
Abstract
Metabolic syndrome is a complex and multifactorial disorder associated with increased risk of cardiovascular disease and type 2 diabetes, exacerbated by a sedentary lifestyle and situations such as the COVID-19 pandemic. Recent studies have shown that consumption of fruits and vegetables high in [...] Read more.
Metabolic syndrome is a complex and multifactorial disorder associated with increased risk of cardiovascular disease and type 2 diabetes, exacerbated by a sedentary lifestyle and situations such as the COVID-19 pandemic. Recent studies have shown that consumption of fruits and vegetables high in polyphenols has a protective effect, reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has recently attracted scientists’ attention due to its potential use in the treatment of metabolic syndrome. This systematic review and meta-analysis examines the effects of HS in combination with other plant extracts on the prevention of metabolic syndrome, exploring their synergistic effects and potential as therapeutic agents. For this purpose, a systematic search of randomized clinical trials (RCTs) was conducted in four different databases and the data obtained were then used for a meta-analysis. Initially, the titles and abstracts of 1368 studies were read. From these, 16 studies were examined closely for their eligibility, and finally, seven RCTs with 332 participants were included in both the meta-analysis and the qualitative analysis. Our results show that HS in combination with other plant extracts improved anthropometric parameters, blood pressure, and lipid profile (low density lipoprotein cholesterol and total cholesterol) compared to a placebo control group. It is important to note that although this meta-analysis suggests that HS in combination with other plant extracts may have a beneficial effect on cardiovascular parameters, further research is needed to determine the optimal dose and intake duration. Full article
(This article belongs to the Special Issue New Insights into Nutraceuticals in the Prevention of Metabolic Syndrome)
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