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Gels
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High-Performance Hydrogel
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High-Performance Hydrogel

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1684

Special Issue Editor

Dr. Jae Hyun Jeong

E-Mail Website
Guest Editor
Department of Chemical Engineering, Soongsil University, Seoul 06978, Republic of Korea
Interests: intelligent and instructive micro-environments for regulating cellular activities; cell-based bio-hybrid actuators and integrated systems; high performance hydrogel systems

Special Issue Information

Dear Colleagues,

In the realm of hydrogel research, the pursuit of high performance has emerged as a driving force behind the innovation and application of these materials. This focused Special Issue, entitled “High-Performance Hydrogel”, aims to provide a platform for the latest developments in hydrogel performance. In this Special Issue, we aim to explore the mechanical robustness, responsive characteristics, and exceptional absorption capabilities that characterize these hydrogels. We also aim to investigate how stability, longevity, and tailored designs contribute to diverse applications in biomedical, environmental, and other cutting-edge fields. As we continue to redefine possibilities, we invite you to join us in unveiling the next generation of high-performance hydrogel.

Dr. Jae Hyun Jeong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanical robustness
  • responsive characteristics
  • exceptional absorption
  • tailored designs
  • biomedical applications
  • environmental applications

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

10 pages, 2712 KiB  
Article
Tailored 3D Agarose-Well Integrated with Human Skin Equivalents for Enhanced Skin Penetration Assessment
by Chaewon Woo, Jina Byun, Sung Gyu Shin, Heeseon Yoo, Sungwoo Cho, Donghun Lee, Taezoon Park and Jae Hyun Jeong
Gels 2024, 10(11), 691; https://doi.org/10.3390/gels10110691 - 24 Oct 2024
Viewed by 651
Abstract
We developed a tailored 3D Agarose-well system integrated with reconstructed human skin equivalents to enhance skin penetration assessments. This system addresses common limitations in traditional trans-well reconstructions, such as dermal layer contraction and limited lateral diffusion, by entangling collagen fibrils within the Agarose-well. [...] Read more.
We developed a tailored 3D Agarose-well system integrated with reconstructed human skin equivalents to enhance skin penetration assessments. This system addresses common limitations in traditional trans-well reconstructions, such as dermal layer contraction and limited lateral diffusion, by entangling collagen fibrils within the Agarose-well. We evaluated the penetration behavior of three peptides, with and without skin-penetrating peptide (SPP) sequences, alongside adenosine, a known anti-wrinkle agent. Despite a SPP having a molecular weight approximately four times greater than that of adenosine, its kinetic constant was similar, with values of about 39 and 34, respectively. Moreover, this living skin equivalent system not only allowed for the evaluation of adenosine penetration, but also demonstrated its biological effects, with adenosine significantly enhancing procollagen synthesis by approximately 23% compared to the control. Overall, this novel strategy holds the potential for tailoring 3D Agarose-wells and advancing high-performance gel development, making it a promising approach for applications in tissue engineering, medical science, regenerative medicine, and cosmetics. Full article
(This article belongs to the Special Issue High-Performance Hydrogel)
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19 pages, 4868 KiB  
Article
Chitosan/Poly(maleic acid-alt-vinyl acetate) Hydrogel Beads for the Removal of Cu2+ from Aqueous Solution
by Irina Popescu, Irina Mihaela Pelin, Dana Mihaela Suflet, Magdalena Cristina Stanciu and Marieta Constantin
Gels 2024, 10(8), 500; https://doi.org/10.3390/gels10080500 - 28 Jul 2024
Viewed by 697
Abstract
Covalent cross-linked hydrogels based on chitosan and poly(maleic acid-alt-vinyl acetate) were prepared as spherical beads. The structural modifications of the beads during the preparation steps (dropping in liquid nitrogen and lyophilization, thermal treatment, washing with water, and treatment with NaOH) were [...] Read more.
Covalent cross-linked hydrogels based on chitosan and poly(maleic acid-alt-vinyl acetate) were prepared as spherical beads. The structural modifications of the beads during the preparation steps (dropping in liquid nitrogen and lyophilization, thermal treatment, washing with water, and treatment with NaOH) were monitored by FT-IR spectroscopy. The hydrogel beads have a porous inner structure, as shown by SEM microscopy; moreover, they are stable in acidic and basic pH due to the covalent crosslinking. The swelling degree is strongly influenced by the pH since the beads possess ionizable amine and carboxylic groups. The binding capacity for Cu2+ ions was examined in batch mode as a function of sorbent composition, pH, contact time, and the initial concentration of Cu2+. The kinetic data were well-fitted with the pseudo-second-order kinetic, while the sorption equilibrium data were better fitted with Langmuir and Sips isotherms. The maximum equilibrium sorption capacity was higher for the beads obtained with a 3:1 molar ratio between the maleic copolymer and chitosan (142.4 mg Cu2+ g−1), compared with the beads obtained using a 1:1 molar ratio (103.7 mg Cu2+ g−1). The beads show a high degree of reusability since no notable decrease in the sorption capacity was observed after five consecutive sorption/desorption cycles. Full article
(This article belongs to the Special Issue High-Performance Hydrogel)
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