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Gels
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Collagen-Based Hydrogels: Volume II
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Collagen-Based Hydrogels: Volume II

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 12465

Special Issue Editor

Dr. Daniela Filipa Duarte Campos

E-Mail Website
Guest Editor
Department of Materials Science & Engineering, Stanford University, Stanford, CA 94305, USA
Interests: bioprinting; biofabrication; tissue/organ engineering; disease modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Collagen is the most abundant protein in the body. Collagen-based hydrogels and hybrids thereof have been extensively used in tissue/organ engineering and drug discovery in past decades. Applications in tissue/organ engineering include vascular grafts, bone and cartilage substitutes, corneal tissue, skin, and dental pulp. In drug discovery, collagen-based hydrogels have been used as platforms for cancer research and in the modeling of other diseases in vitro. Advances in biomanufacturing methods such as 3D/4D bioprinting and biofabrication have attracted attention regarding the development of collagen-based hydrogels as bioinks suitable to these technologies. Intelligent, stimuli-responsive, and reversibly crosslinkable collagen-based hydrogels with self-healing properties were recently used as injectable hydrogels for drug delivery and regenerative medicine, as bioinks for biomanufacturing and tissue engineering, and as in vitro models to study mechanobiological details at the cell–biomaterial interface. This Special Issue on “Collagen-Based Hydrogels” invites the submission of original research, opinions, and review articles on topics including the use of collagen-based hydrogels in in vitro, in situ, and in vivo studies in the fields of tissue/organ engineering, disease modeling, and drug discovery.

Dr. Daniela Filipa Duarte Campos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Collagen hydrogel
  • Responsive hydrogel
  • Hybrid hydrogel
  • Tissue/organ engineering
  • Disease modeling
  • Drug discovery
  • Bioprinting
  • Biofabrication
  • In vitro/in situ/in vivo

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Related Special Issue

Published Papers (2 papers)

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15 pages, 4601 KiB  
Article
A Collagen-Mimetic Organic-Inorganic Hydrogel for Cartilage Engineering
by Laurine Valot, Marie Maumus, Luc Brunel, Jean Martinez, Muriel Amblard, Danièle Noël, Ahmad Mehdi and Gilles Subra
Gels 2021, 7(2), 73; https://doi.org/10.3390/gels7020073 - 15 Jun 2021
Cited by 15 | Viewed by 3352
Abstract
Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the injured joint. Preclinical and clinical data using MSCs embedded in a collagen gel have demonstrated improvements in patients with focal [...] Read more.
Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the injured joint. Preclinical and clinical data using MSCs embedded in a collagen gel have demonstrated improvements in patients with focal lesions and osteoarthritis. However, an improvement is often observed in the short or medium term due to the loss of the chondrocyte capacity to produce the correct extracellular matrix and to respond to mechanical stimulation. Developing novel biomimetic materials with better chondroconductive and mechanical properties is still a challenge for cartilage engineering. Herein, we have designed a biomimetic chemical hydrogel based on silylated collagen-mimetic synthetic peptides having the ability to encapsulate MSCs using a biorthogonal sol-gel cross-linking reaction. By tuning the hydrogel composition using both mono- and bi-functional peptides, we succeeded in improving its mechanical properties, yielding a more elastic scaffold and achieving the survival of embedded MSCs for 21 days as well as the up-regulation of chondrocyte markers. This biomimetic long-standing hybrid hydrogel is of interest as a synthetic and modular scaffold for cartilage tissue engineering. Full article
(This article belongs to the Special Issue Collagen-Based Hydrogels: Volume II)
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Review

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35 pages, 4016 KiB  
Review
Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels
by Xabier Morales, Iván Cortés-Domínguez and Carlos Ortiz-de-Solorzano
Gels 2021, 7(1), 17; https://doi.org/10.3390/gels7010017 - 12 Feb 2021
Cited by 23 | Viewed by 8511
Abstract
Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsible for most cancer-related deaths. In this article [...] Read more.
Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsible for most cancer-related deaths. In this article we review the state of the art about the use of hydrogel-based three-dimensional (3D) scaffolds as artificial platforms to model the mechanobiology of cancer cell migration. We start by briefly reviewing the concept and composition of the extracellular matrix (ECM) and the materials commonly used to recreate the cancerous ECM. Then we summarize the most relevant knowledge about the mechanobiology of cancer cell migration that has been obtained using 3D hydrogel scaffolds, and relate those discoveries to what has been observed in the clinical management of solid tumors. Finally, we review some recent methodological developments, specifically the use of novel bioprinting techniques and microfluidics to create realistic hydrogel-based models of the cancer ECM, and some of their applications in the context of the study of cancer cell migration. Full article
(This article belongs to the Special Issue Collagen-Based Hydrogels: Volume II)
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