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MicroRNAs in Eye Development and Diseases
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MicroRNAs in Eye Development and Diseases

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (25 December 2023) | Viewed by 2177

Special Issue Editors

Prof. Dr. Colin E. Willoughby

E-Mail Website
Guest Editor
Genomic Medicine Group, Biomedical Sciences Research Institute, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK
Interests: microRNAs; ophthalmology; glaucoma; trabecular meshwork; fibrosis; oxidative stress; mitochondria; TGFβ; gene therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Jing Chen

E-Mail Website
Guest Editor
Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Interests: microRNA; nuclear receptor; wnt signaling; angiogenesis; blood–retinal barrier; retinal pigment epithelium; retinopathy; age-related macular degeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) are small regulatory RNAs involved in controlling gene expression in physiological and pathological states. MiRNAs play important roles in all ocular tissues and we hope this Special Issue will highlight their roles in both ocular development and multiple ocular conditions. MiRNA expression is cell- and context-specific and numerous miRNAs have been implicated in eye development and ocular disorders. Dysregulated miRNA expression provides insight into the patho-physiological process implicated in eye disease and pathology. MiRNAs have been investigated as biomarkers of ocular disease, providing diagnostic and prognostic information as well as disease stratification. The unique physiology of the eye has leant itself to the clinical development and adoption of gene therapies. The potential to manipulate microRNAs for clinical benefit has raised the possibility of new classes of therapeutic agents for ocular diseases. Investigation into multiple model organisms has advanced our knowledge on the basic mechanisms of miRNA regulation and dysregulation in ocular development and diseases. In this Special Issue, we wish to bring together a collection of papers that highlight the roles of microRNAs in ocular development, health and diseases from both clinical and experimental studies. 

Prof. Dr. Colin E. Willoughby
Dr. Jing Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • miRNA
  • gene expression
  • eye
  • retina
  • cornea
  • retinal pigment epithelium
  • lens
  • vasculature
  • ophthalmology
  • development
  • glaucoma
  • retinopathy
  • diabetes
  • retinal degeneration
  • age-related macular degeneration
  • cataracts
  • oncology
  • vision
  • biomarkers
  • gene therapy
  • nanotechmology

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Published Papers (1 paper)

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Research

18 pages, 4248 KiB  
Article
Small RNA Sequencing Reveals a Distinct MicroRNA Signature between Glucocorticoid Responder and Glucocorticoid Non-Responder Primary Human Trabecular Meshwork Cells after Dexamethasone Treatment
by Kandasamy Kathirvel, Xiaochen Fan, Ravinarayanan Haribalaganesh, Devarajan Bharanidharan, Rajendrababu Sharmila, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Colin E. Willoughby and Srinivasan Senthilkumari
Genes 2023, 14(11), 2012; https://doi.org/10.3390/genes14112012 - 27 Oct 2023
Cited by 3 | Viewed by 1764
Abstract
Glucocorticoids (GCs) are known to regulate several physiological processes and are the mainstay in the management of inflammatory eye diseases. The long-term use of GC causes raised intraocular pressure (IOP) or ocular hypertension (OHT) in about 30–50% of the susceptible individuals depending on [...] Read more.
Glucocorticoids (GCs) are known to regulate several physiological processes and are the mainstay in the management of inflammatory eye diseases. The long-term use of GC causes raised intraocular pressure (IOP) or ocular hypertension (OHT) in about 30–50% of the susceptible individuals depending on the route of administration, and can lead to steroid-induced secondary glaucoma. The present study aims to understand the role of microRNAs (miRNAs) in differential glucocorticoid (GC) responsiveness in human trabecular meshwork (HTM) cells using small RNA sequencing. The human organ-cultured anterior segment (HOCAS) model was used to identify whether donor eyes were from GC-responders (GC-R; n = 4) or GC-non-responders (GC-NR; n = 4) following treatment with either 100 nM dexamethasone (DEX) or ethanol (ETH) for 7 days. The total RNA was extracted from cultured HTM cells with known GC responsiveness, and the differentially expressed miRNAs (DEMIRs) were compared among the following five groups: Group #1: ETH vs. DEX-treated GC-R; #2: ETH vs. DEX-treated GC-NR; #3: overlapping DEGs between Group #1 and #2; #4: Unique DEMIRs of GC-R; #5: Unique DEMIRs of GC-NR; and validated by RT-qPCR. There were 13 and 21 DEMIRs identified in Group #1 and Group #2, respectively. Seven miRNAs were common miRNAs dysregulated in both GC-R and GC-NR (Group #3). This analysis allowed the identification of DEMIRs that were unique to GC-R (6 miRNAs) and GC-NR (14 miRNAs) HTM cells, respectively. Ingenuity Pathway Analysis identified enriched pathways and biological processes associated with differential GC responsiveness in HTM cells. This is the first study to reveal a unique miRNA signature between GC-R and GC-NR HTM cells, which raises the possibility of developing new molecular targets for the management of steroid-OHT/glaucoma. Full article
(This article belongs to the Special Issue MicroRNAs in Eye Development and Diseases)
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