Immunogenomics in Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 5 April 2025 | Viewed by 222
Special Issue Editor
Interests: cancer (urogenital, ovarian, haematological); endocrinology; autoimmunity; immunology; genomics; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The immune system can recognize and attempt to reject cancer cells as foreign; however, cancer cells can develop ways to evade immune surveillance. Neoantigens, which are defined as highly cancer-specific proteins, generated from somatic mutations in individual patients, play pivotal roles in the development of anti-cancer immunity. More specifically, neo-antigens may influence responses against cancer therapy, including cancer immunotherapies.
Immunogenomics stands at the forefront of today’s research against cancer. The field itself combines immunology and genomics. More specifically, it includes the identification and analysis of genetic variations, mutations, and alterations in both cancer cells and the immune system. Understanding the genetic landscape of both the tumor and the host immune system will provide researchers with tools to develop personalized and precise cancer immunotherapies.
Today, novel technologies and disciplines including next generation sequencing and computational biology allow for more effective study of immune response genetics against neoantigens and therapeutic regimes.
The aim of this Special Issue is to shed light on the genetics and genomics of the immune response against cancer. Novel research articles, letters, and review papers are welcome in order to form a collection of significant research items that promote the subject of immunogenomics in cancer.
Dr. Nikos G. Gavalas
Guest Editor
Manuscript Submission Information
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Keywords
- immunogenomics
- cancer
- neoantigens
- genetic variations
- response
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