Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 23
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, liver transplantation has undergone major changes, as seen in the progressive reduction in viral liver disease and the increase in MASLD, and the ever-increasing indications in transplant oncology (intrahepatic and peri-hilar cholangiocarcinoma, and non-resectable liver metastasis). At the same time, the use of livers from extended-criteria donors, including grafts from very old donors and severely steatotic grafts, as well as those following cardiac death, has increased. These grafts are managed appropriately using machine perfusion—hypothermic oxygenate (HOPE) or normothermic (NMP)—which allows for the dynamic preservation of organs and enhances early allograft function, reducing ischemia–reperfusion injury.
NMP also serves as a platform for therapeutic interventions during ex situ liver preservation and is capable of delivering therapeutic agents to improve ischemia–reperfusion injury and liver steatosis, as well as promoting immunomodulation and endothelial protection. In the near future, targeted antimicrobial drugs could be delivered during NMP in grafts from infected donors, with the perfusate being tested for microbiological growth before transplantation.
Future challenges could include the transplantation of human liver stem-like cells (HLSCs)—a mesenchymal-like progenitor cell population with a self-renewing capability derived from human adult liver tissue—to treat monogenic inherited liver diseases.
This Special Issue focuses on recent research progress on the pathogenesis, therapeutic strategies and future challenges in liver transplantation. We invite experts interested in this issue to submit original manuscripts and reviews on any of the above-mentioned topics relevant at the molecular level.
Dr. Francesco Tandoi
Guest Editor
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Keywords
- MASLD
- transplant oncology
- machine perfusion
- extended-criteria donors
- donors after cardiac death
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