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Hypertension and Dyslipidemia: From Pathogenesis to Therapeutic Perspective
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Hypertension and Dyslipidemia: From Pathogenesis to Therapeutic Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 8226

Special Issue Editor

Prof. Dr. Ilya Nikolaevich Medvedev

E-Mail Website
Guest Editor
Department of Mechanics and Mathematics, Russian State Social University, Moscow 119992, Russia
Interests: platelets; animal physiology; ontogenesis; cardiology; arterial hypertension; metabolic disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Recently, among the population of developed countries, arterial hypertension is increasingly common, which is aggravated by dyslipidemia. Isolated arterial hypertension causes many different disorders in the body. In the case of its combination with dyslipidemia, the number of disorders increases even more, and the risk of vascular complications increases many times over. In this condition, the development of atherosclerosis in different vascular regions is intensified, the mechanisms of hemostasis are disrupted, which creates conditions for the occurrence of vascular complications. The active treatment used for arterial hypertension and dyslipidemia is far from being effective in all cases, and these patients often lose their ability to work and become disabled. For this reason, it is important to continue studying aspects of the pathogenesis of the combination of arterial hypertension and dyslipidemia and approaches to its correction.

Dr. Ilya Nikolaevich Medvedev
Guest Editor

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Keywords

  • arterial hypertension
  • dyslipidemia
  • complication of the disease
  • vascular disorders
  • hemostasiopathy
  • thrombosis
  • antihypertensive therapy
  • lipid-lowering therapy
  • exercise
  • dietary treatment

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Published Papers (2 papers)

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Review

21 pages, 1094 KiB  
Review
Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications
by Andrijana Koceva, Rok Herman, Andrej Janez, Matej Rakusa and Mojca Jensterle
Int. J. Mol. Sci. 2024, 25(13), 7342; https://doi.org/10.3390/ijms25137342 - 4 Jul 2024
Cited by 2 | Viewed by 2460
Abstract
Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiology and clinical implications, the impact of sex is typically overlooked in obesity research. Worldwide, women [...] Read more.
Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiology and clinical implications, the impact of sex is typically overlooked in obesity research. Worldwide, women have a higher likelihood to become obese compared to men. Although women are offered weight loss interventions more often and at earlier stages than men, they are more vulnerable to psychopathology. Men, on the other hand, are less likely to pursue weight loss intervention and are more susceptible to the metabolic implications of obesity. In this narrative review, we comprehensively explored sex- and gender-specific differences in the development of obesity, focusing on a variety of biological variables, such as body composition, fat distribution and energy partitioning, the impact of sex steroid hormones and gut microbiota diversity, chromosomal and genetic variables, and behavioural and sociocultural variables influencing obesity development in men and women. Sex differences in obesity-related comorbidities and varying effectiveness of different weight loss interventions are also extensively discussed. Full article
(This article belongs to the Special Issue Hypertension and Dyslipidemia: From Pathogenesis to Therapeutic Perspective)
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21 pages, 1563 KiB  
Review
Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?
by Gabriele Brosolo, Andrea Da Porto, Stefano Marcante, Alessandro Picci, Filippo Capilupi, Patrizio Capilupi, Nicole Bertin, Cinzia Vivarelli, Luca Bulfone, Antonio Vacca, Cristiana Catena and Leonardo A. Sechi
Int. J. Mol. Sci. 2023, 24(11), 9520; https://doi.org/10.3390/ijms24119520 - 30 May 2023
Cited by 14 | Viewed by 5135
Abstract
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements. Many epidemiological [...] Read more.
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements. Many epidemiological and retrospective studies suggested that ω-3 PUFA consumption decreases the risk of cardiovascular disease, but results of early intervention trials have not consistently confirmed this effect. In recent years, some large-scale randomized controlled trials have shed new light on the potential role of ω-3 PUFAs, particularly high-dose EPA-only formulations, in cardiovascular prevention, making them an attractive tool for the treatment of “residual” cardiovascular risk. ω-3 PUFAs' beneficial effects on cardiovascular outcomes go far beyond the reduction in triglyceride levels and are thought to be mediated by their broadly documented “pleiotropic” actions, most of which are directed to vascular protection. A considerable number of clinical studies and meta-analyses suggest the beneficial effects of ω-3 PUFAs in the regulation of blood pressure in hypertensive and normotensive subjects. These effects occur mostly through regulation of the vascular tone that could be mediated by both endothelium-dependent and independent mechanisms. In this narrative review, we summarize the results of both experimental and clinical studies that evaluated the effect of ω-3 PUFAs on blood pressure, highlighting the mechanisms of their action on the vascular system and their possible impact on hypertension, hypertension-related vascular damage, and, ultimately, cardiovascular outcomes. Full article
(This article belongs to the Special Issue Hypertension and Dyslipidemia: From Pathogenesis to Therapeutic Perspective)
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