Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 1064
Special Issue Editor
Interests: molecular biology; neurogenetics; motor neuron diseases; amyotrophic lateral sclerosis; gene variants; gene regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are a heterogeneous group of disorders, largely age-dependent, affecting the central nervous system and eventually leading to neurodegeneration. The prevalence of these diseases is increasing, partly due to the aging population, with a consequent growing economic burden on healthcare systems. The current treatments are mostly symptomatic, without affecting the underlying cause of disease, and have no or only slight effects on disease progression.
Recent advancements in neurobiology and neurogenetics have provided valuable insights into the pathogenesis of neurodegenerative diseases. This has paved the way for the development of molecularly targeted therapies, which are able to pause or slow the fundamental pathological processes that cause neuronal damage and consequent cognitive and motor dysfunctions. In some cases, neurodegenerative diseases are caused by genetic variants and/or cellular pathway dysregulation. Some mechanisms common to several neurodegenerative conditions have been identified, such as the presence of misfolded protein aggregates, the abnormal accumulation of proteins, RNA toxicity, or translational products from the expansion of repeats within genes. As advances are made in understanding critical aspects of the underlying molecular pathophysiology, therapeutic strategies continue to evolve. Among these, gene therapy is attracting great interest due to the possibility to deliver functional genetic material to cells to correct a defective gene.
This Special Issue aims to provide an updated overview of the advancements in the research on neurodegenerative diseases, from the understanding of the molecular bases to the development of new therapies. Contributions related but not limited to Alzheimer's disease and other types of dementia, Parkinson's disease and motor neuron diseases are welcome, including original research articles and full and short reviews.
Dr. Claudia Ricci
Guest Editor
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Keywords
- neurodegenerative diseases
- molecular biology
- neurogenetics
- pathogenesis
- therapy
- personalized medicine
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