Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 2544
Special Issue Editor
Interests: cell biology; immunology; immunomodulation; biomarkers; autoimmune diseases; allergy; cytotoxicity; anticancer activity; natural products; probiotics; prebiotics; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The main reason for the high economic and social burden of cancer is the lack of effective drug agents and therapies. Therefore, the efforts of a large part of the scientific community are directed at identifying new anticancer compounds from natural sources (plants, algae or other organisms) as well as developing new formulations in order to increase the healing potential and minimize the side effects of currently used therapeutic agents. Thus, the search for new biologically active compounds is important for the discovery of new drugs relative to the treatment of cancer.
Evaluation of the anticancer activity is performing by detection of specific cytotoxicity of the test agent, affecting fundamental cellular functions of cancer cells causing their death. Changes in metabolic processes (e.g., mitochondrial activity) and the level of ATP or free radicals are early indicators of cell damage. Disruption of the plasma membrane integrity increases the concentration of enzymes in the extracellular environment, which together with the DNA fragmentation are key parameters for assessing the cell damage. Therefore, anticancer activity is assessed on the basis of specific cytotoxicity observed by examining the basic parameters of cell damage.
This Special Issue aims to publish original research studies related to the isolation and characterization of natural products with anticancer activity as well as their molecular mechanisms of action or effects on a particular metabolic or signalling pathway. Authors are invited to submit their high-quality articles, reviews or short communications concerning this topic. Multidisciplinary studies involving in vitro and/or in vivo experiments that address specific delivery of anticancer drugs by using different novel technologies based on natural products are also welcome.
Importantly, the exact active ingredient of plant extract must be reported in the submitted research manuscript, since papers describing effects of mixed extraction from plants will not be accepted. More published papers could be found in the closed Special Issue: Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products.
Prof. Dr. Balik Dzhambazov
Guest Editor
Manuscript Submission Information
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Keywords
- natural products
- anticancer activity
- apoptosis
- immunomodulation
- free radicals
- proliferation
- phytomolecules
- nanoparticles
- drug delivery
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