Tumor Microenvironment: Molecular Mechanism and Signaling Pathway Involved in Cancer Metastasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3213
Special Issue Editors
Interests: gynecological oncology; endometrial cancer; metastasis; translational research; biomarkers.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumors are highly complex entities composed of a plethora of cell types, which altogether comprise what we call the “tumor microenvironment” (TME). Such an ecosystem contains immune, endothelial or nerve cells, as well as fibroblasts, which dynamically interact with cancer cells both at the physical and biochemical levels. Such interactions lead to acute and chronic alterations in the phenotypic characteristics of cancer and non-cancer cells, ultimately affecting tumor progression. Of particular relevance is the effect that the TME exerts over the migratory and invasive capacities of cancer cells, regulating regional and distant tumor dissemination through metastasis formation, a key feature that determines the survival of cancer patients. Understanding the TME-related mechanisms and signaling pathways related to tumor invasion and metastatic dissemination, as well as immunosuppression and therapy resistance, will provide a more detailed view of the biology of tumor progression and an opportunity to design new therapeutic approaches, specifically tackling metastasis formation.
For this Special Issue of the International Journal of Molecular Sciences, we invite authors to submit original and review articles that provide new insights on how the TME influences tumor dissemination and metastasis. Articles covering new findings on TME-related mechanisms altering cancer motility, invasion, angiogenesis, hematogenous, or lymphatic dissemination, as well as immune evasion or therapy resistance, are welcomed.
Dr. Miguel Abal
Dr. Jorge Barbazán
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
