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Medical Applications for 3D Bioprinting
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Medical Applications for 3D Bioprinting

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 14212

Special Issue Editors

Dr. Isabel Andia

E-Mail Website
Guest Editor
Bioprinting Laboratory, Regenerative Therapies, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza Cruces 12, 48903 Barakaldo, Bizkaia, Spain
Interests: healing mechanisms; orthobiologics; sports injuries; regenerative medicine technologies; wound management
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giovanna Della Porta

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: drug delivery; micro/nano carriers; new technologies for drug carriers development; innovative drug carriers; biopolymers; liposomes; nanogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioprinting technologies have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, and are currently being used for the manufacture of tissue constructs in tissue engineering and regenerative medicine.

However, many challenging intricacies have to be met before bioprinting technologies achieve their full potential. Novel smart bioinks have to recreate complex tissues and the crosstalk between the different cell phenotypes; in addition, their attributes need to be tailored to the bioprinting modality.

The current Special Issue will cover a selection of articles that inform about novel bioink development, especially for bone, cartilage, tendon/ligament, muscle, and skin. Up-to-date reviews and original papers related to any aspect of medical applications (i.e., creating models for disease research, toxicity screening, functional drug evaluation, or translational clinical research) are welcome.

Dr. Isabel Andia
Prof. Giovanna Della Porta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Review

29 pages, 12242 KiB  
Review
Tissue-Specific Decellularized Extracellular Matrix Bioinks for Musculoskeletal Tissue Regeneration and Modeling Using 3D Bioprinting Technology
by Wonbin Park, Ge Gao and Dong-Woo Cho
Int. J. Mol. Sci. 2021, 22(15), 7837; https://doi.org/10.3390/ijms22157837 - 22 Jul 2021
Cited by 43 | Viewed by 7469
Abstract
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including [...] Read more.
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including donor site morbidity and immunoreaction, exist. To overcome these limitations, various biomedical engineering approaches have been proposed based on an understanding of the complexity of human musculoskeletal tissue. In this review, the leading edge of musculoskeletal tissue engineering using 3D bioprinting technology and musculoskeletal tissue-derived decellularized extracellular matrix bioink is described. In particular, studies on in vivo regeneration and in vitro modeling of musculoskeletal tissue have been focused on. Lastly, the current breakthroughs, limitations, and future perspectives are described. Full article
(This article belongs to the Special Issue Medical Applications for 3D Bioprinting)
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28 pages, 2564 KiB  
Review
Overview of Current Advances in Extrusion Bioprinting for Skin Applications
by Arantza Perez-Valle, Cristina Del Amo and Isabel Andia
Int. J. Mol. Sci. 2020, 21(18), 6679; https://doi.org/10.3390/ijms21186679 - 12 Sep 2020
Cited by 50 | Viewed by 5405
Abstract
Bioprinting technologies, which have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, are currently being exploited for the fabrication of human skin in regenerative medicine. We performed a systematic review to appraise the latest [...] Read more.
Bioprinting technologies, which have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, are currently being exploited for the fabrication of human skin in regenerative medicine. We performed a systematic review to appraise the latest advances in 3D bioprinting for skin applications, describing the main cell phenotypes, signaling proteins, and bioinks used in extrusion platforms. To understand the current limitations of this technology for skin bioprinting, we briefly address the relevant aspects of skin biology. This field is in the early stage of development, and reported research on extrusion bioprinting for skin applications has shown moderate progress. We have identified two major trends. First, the biomimetic approach uses cell-laden natural polymers, including fibrinogen, decellularized extracellular matrix, and collagen. Second, the material engineering line of research, which is focused on the optimization of printable biomaterials that expedite the manufacturing process, mainly involves chemically functionalized polymers and reinforcement strategies through molecular blending and postprinting interventions, i.e., ionic, covalent, or light entanglement, to enhance the mechanical properties of the construct and facilitate layer-by-layer deposition. Skin constructs manufactured using the biomimetic approach have reached a higher level of complexity in biological terms, including up to five different cell phenotypes and mirroring the epidermis, dermis and hypodermis. The confluence of the two perspectives, representing interdisciplinary inputs, is required for further advancement toward the future translation of extrusion bioprinting and to meet the urgent clinical demand for skin equivalents. Full article
(This article belongs to the Special Issue Medical Applications for 3D Bioprinting)
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