The Role of the Mitochondria in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 1442
Special Issue Editor
2. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
3. Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain
Interests: metabolic diseases; mitochondria; membrane contact sites; transport of lipids and phospholipids
Special Issue Information
Dear Colleagues,
The tight regulation of core cellular metabolic pathways is essential for tissue homeostasis and stress resistance. In this regard, the mitochondria are gatekeepers of metabolic homeostasis by integrating the lipid, carbohydrate, and amino acid metabolism with energy production. Besides controlling respiration and ATP synthesis, the mitochondria are central regulators of many other cellular functions, such as calcium homeostasis, autophagy, apoptosis, phospholipid synthesis, and senescence. They also function as hubs integrating responses to cellular stress. However, the exact mechanisms behind these changes and whether they represent a compensation or a dysfunction are still unclear. Studies performed in human and animal models have demonstrated a connection between deficient mitochondrial activity in different tissues and the development of metabolic diseases. Although the implication of the mitochondria in these diseases is clear, much less is known about the molecular mechanisms and specific mitochondrial alterations responsible for their development and the crosstalk between these alterations and other metabolic pathways. Therefore, advances in this knowledge could facilitate the design and development of novel therapeutic tools for the prevention or treatment of these disorders.
In this Special Issue, we invite investigators to contribute original research and review articles addressing the role of the metabolism and the mitochondria (alongside mitochondria–organelle crosstalk) in different tissues during metabolic disease development. We encourage submissions that elucidate novel molecular mechanisms related to the mitochondria (mitochondrial function, dynamics, and contact sites), mitochondrial-derived metabolites, and metabolic regulation in mammalian cells, mouse models, or humans, and their potential role in the pathogenesis and/or diagnosis of the aforementioned diseases.
Dr. María Isabel Hernández-Alvarez
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- mitochondria contact sites
- metabolism
- lipids
- metabolites
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
