Role of NLRP3 Inflammasome in Inflammatory and Immunological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 August 2024) | Viewed by 1709
Special Issue Editor
Interests: neuroimmunology; neurological diseases and inflammasome biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The NLRP3 inflammasome is a multimeric protein complex machinery consisting of three subunits: the sensor-NLRP3, an adaptor-ASC subunit, and the effector-caspase-1. Caspase-1 converts the pro-inflammatory cytokine pro-IL1B to the active form IL1B. Recent studies have elucidated the role of the inflammasome in various inflammatory and immunological diseases. A common theme among these diseases is the correlation between increased levels of NLRP3 and/or its product IL1B and the worsening of the disease.
Based on these observations, many studies have suggested targeting the NLRP3 inflammasome as a strategy for designing new therapeutic drug molecules. However, there remain several unanswered questions that need to be addressed, such as whether the NLRP3 inflammasome is a common target for the inflammatory state of the disease and whether we are close to finding a treatment by reducing the inflammation.
In this review, we aim to comprehensively cover all known relevant information about the NLRP3 inflammasome. This includes its structure, the different pathways involved (canonical and non-canonical), its roles in various inflammatory or immunological diseases, and how targeting the NLRP3 inflammasome can serve as a key strategy to uncover hidden secrets and pave the way for potential therapeutic interventions.
In this Special Issue, original research articles and reviews are welcome.
I look forward to receiving your contributions.
Dr. Sunny Malhotra
Guest Editor
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Keywords
- NLRP3 inflammasome
- immunological diseases
- therapeutic target
- inflammation
- immune-response
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