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New Therapeutic Strategies for Lung Cancer: An Update

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 4615

Special Issue Editor


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Guest Editor
1. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy National Cance Center, Goyang 10408, Republic of Korea
2. Department of Bio-Healthcare, Hwasung Medi-Science University, Hwaseong-si 18274, Republic of Korea
Interests: molecular mechanism; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); post-translational modification (PTM); autophagy; potential therapeutic approaches; preclinical mouse models for cancers; breast cancer; liver cancer; lung cancer; pancreatic cancer; cancer progression and metastasis
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Special Issue Information

Dear Colleagues, 

Lung cancer is the leading cancer cause of death worldwide in recent decades, mainly divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Lung metastasis is regulated by several elements, such as the interactions among various types of signaling in the lung cancer microenvironment and epithelial–mesenchymal transition (EMT). At the same time, there have been significant advances in lung cancer therapies, such as chemotherapy, targeted therapy, radiotherapy, and miRNA-based therapy immunotherapy.

This Special Issue on “New Therapeutic Strategies for Lung Cancer: An Update” aims to provide value for future investigations and promising therapeutic clues. It is also focused on the discovery of molecular insights and potential therapeutic approaches. Authors are invited to submit original research and topical review articles related to these topics.

Dr. Mi Kyung Park
Guest Editor

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Keywords

  • lung cancer
  • lung metastasis
  • epithelial–mesenchymal transition (EMT)
  • lung cancer therapeutics
  • mouse models of lung cancer
  • tumor microenvironment

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Published Papers (1 paper)

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Review

27 pages, 1722 KiB  
Review
Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent
by Lu Yu, Ho Lee, Seung Bae Rho, Mi Kyung Park and Chang Hoon Lee
Int. J. Mol. Sci. 2023, 24(7), 6712; https://doi.org/10.3390/ijms24076712 - 4 Apr 2023
Cited by 3 | Viewed by 4153
Abstract
Ethacrynic acid (ECA) is a diuretic that inhibits Na-K-2Cl cotransporter (NKCC2) present in the thick ascending loop of Henle and muculo dens and is clinically used for the treatment of edema caused by excessive body fluid. However, its clinical use is limited due [...] Read more.
Ethacrynic acid (ECA) is a diuretic that inhibits Na-K-2Cl cotransporter (NKCC2) present in the thick ascending loop of Henle and muculo dens and is clinically used for the treatment of edema caused by excessive body fluid. However, its clinical use is limited due to its low bioavailability and side effects, such as liver damage and hearing loss at high doses. Despite this, ECA has recently emerged as a potential anticancer agent through the approach of drug repositioning, with a novel mechanism of action. ECA has been shown to regulate cancer hallmark processes such as proliferation, apoptosis, migration and invasion, angiogenesis, inflammation, energy metabolism, and the increase of inhibitory growth factors through various mechanisms. Additionally, ECA has been used as a scaffold for synthesizing a new material, and various derivatives have been synthesized. This review explores the potential of ECA and its derivatives as anticancer agents, both alone and in combination with adjuvants, by examining their effects on ten hallmarks of cancer and neuronal contribution to cancer. Furthermore, we investigated the trend of synthesis research of a series of ECA derivatives to improve the bioavailability of ECA. This review highlights the importance of ECA research and its potential to provide a cost-effective alternative to new drug discovery and development for cancer treatment. Full article
(This article belongs to the Special Issue New Therapeutic Strategies for Lung Cancer: An Update)
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