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Molecular Mechanisms of Anticancer Strategies of Natural Active Substances

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 6044

Special Issue Editor


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Guest Editor
Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China
Interests: natural active substances; anticancer

Special Issue Information

Dear Colleagues,

Anticancer is a wide range idea on research, diagnosis, treatment, prevention, and recovery of cancer-related issues. Given the fact that cancer is a complex disease involving multiple pathogenetic mechanisms, the attention of researchers has been drawn to the strategies of anticancer, e.g., anticancer active substances from natural resources. To explore the active components via phytochemistry methods allows for the identification of specific targets for each individual tumor. The principle of anticancer by using the active components is based on interference with the mechanisms that regulate the life and proliferation of cancer cells, causing their death or through the effect in immune system. In recent years, more and more scientists continuously work on the development of natural active substances against cancer, which has become one of the important strategies of anticancer.

In this Special Issue, we focus attention on new anticancer agents from natural resources and related targets of different cancers. We welcome the submission of research articles on the advances in discovery, application, and development of new compounds with potency against various cancer types.

Dr. Huangquan Lin
Guest Editor

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Keywords

  • phytochemical
  • anticancer
 

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Published Papers (3 papers)

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Research

21 pages, 7889 KiB  
Article
TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways
by Mafia Mahabub Rumpa and Camelia Maier
Int. J. Mol. Sci. 2024, 25(10), 5258; https://doi.org/10.3390/ijms25105258 - 11 May 2024
Cited by 1 | Viewed by 1843
Abstract
Globally, breast cancer is a significant cause of mortality. Recent research focused on identifying compounds regulating the transient receptor potential vanilloid 1 (TRPV1) ion channel activity for the possibility of developing cancer therapeutics. In this study, the antiproliferative properties and mechanisms of action [...] Read more.
Globally, breast cancer is a significant cause of mortality. Recent research focused on identifying compounds regulating the transient receptor potential vanilloid 1 (TRPV1) ion channel activity for the possibility of developing cancer therapeutics. In this study, the antiproliferative properties and mechanisms of action through TRPV1 of Maclura pomifera, a dioecious tree native to the south-central USA, have been investigated. Male and female extracts of spring branch tissues and leaves (500 µg/mL) significantly reduced the viability of MCF-7 and T47D cells by 75–80%. M. pomifera extracts induced apoptosis by triggering intracellular calcium overload via TRPV1. Blocking TRPV1 with the capsazepine antagonist and pretreating cells with the BAPTA-AM chelator boosted cell viability, revealing that M. pomifera phytochemicals activate TRPV1. Both male and female M. pomifera extracts initiated apoptosis through multiple pathways, the mitochondrial, ERK-induced, and endoplasmic reticulum-stress-mediated apoptotic pathways, demonstrated by the expression of activated caspase 3, caspase 9, caspase 8, FADD, FAS, ATF4, and CHOP, the overexpression of phosphorylated PERK and ERK proteins, and the reduction of BCL-2 levels. In addition, AKT and pAKT protein expressions were reduced in female M. pomifera-treated cells, revealing that female plant extract also inhibits PI3K/Akt signaling pathways. These results suggest that phytochemicals in M. pomifera extracts could be promising for developing breast cancer therapeutics. Full article
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19 pages, 3674 KiB  
Communication
In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation
by Roberta Macrì, Irene Bava, Federica Scarano, Rocco Mollace, Vincenzo Musolino, Micaela Gliozzi, Marta Greco, Daniela Foti, Luigi Tucci, Jessica Maiuolo, Cristina Carresi, Annamaria Tavernese, Ernesto Palma, Carolina Muscoli and Vincenzo Mollace
Int. J. Mol. Sci. 2023, 24(16), 12735; https://doi.org/10.3390/ijms241612735 - 13 Aug 2023
Cited by 3 | Viewed by 1654
Abstract
The clinical use of anthracycline Doxorubicin as an antineoplastic drug in cancer therapy is limited by cardiotoxic effects that can lead to congestive heart failure. Recent studies have shown several promising activities of different species of the genus Ferula belonging to the Apiaceae [...] Read more.
The clinical use of anthracycline Doxorubicin as an antineoplastic drug in cancer therapy is limited by cardiotoxic effects that can lead to congestive heart failure. Recent studies have shown several promising activities of different species of the genus Ferula belonging to the Apiaceae Family. Ferula communis is the main source of Ferutinin—a bioactive compound isolated from many species of Ferula—studied both in vitro and in vivo because of their different effects, such as estrogenic, antioxidant, anti-inflammatory, and also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. However, the potential protective role of Ferutinin in myocardium impairment, caused by chemotherapeutic drugs, still represents an unexplored field. The aim of this study was to test the effects of Ferutinin rich-Ferula communis L. root extract (FcFE) at different concentrations on H9C2 cells. Moreover, we evaluated its antioxidant properties in cardiomyocytes in order to explore new potential therapeutic activities never examined before in other experimental works. FcFE, at a concentration of 0.25 µM, in the H9C2 line, significantly reduced the ROS production induced by H2O2 (50 µM and 250 µM) and traced the cell mortality of the H9C2 co-treated with Ferutinin 0.25 µM and Doxorubicin (0.5 µM and 1 µM) to control levels. These results showed that FcFE could protect against Doxorubicin-induced cardiotoxicity. Further molecular characterization of this natural compound may open the way for testing FcFE at low concentrations in vivo and in clinical studies as an adjuvant in cancer therapy in association with anthracyclines to prevent side effects on heart cells. Full article
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26 pages, 14657 KiB  
Article
Antiproliferative, Antioxidant, Chemopreventive and Antiangiogenic Potential of Chromatographic Fractions from Anemonia sulcata with and without Its Symbiont Symbiodinium in Colorectal Cancer Therapy
by Mercedes Peña, Cristina Mesas, Gloria Perazzoli, Rosario Martínez, Jesús M. Porres, Kevin Doello, Jose Prados, Consolación Melguizo and Laura Cabeza
Int. J. Mol. Sci. 2023, 24(14), 11249; https://doi.org/10.3390/ijms241411249 - 8 Jul 2023
Cited by 2 | Viewed by 1885
Abstract
Anemonia sulcata may be a source of marine natural products (MNPs) due to the antioxidant and antitumor activity of its crude homogenates shown in vitro in colon cancer cells. A bioguided chromatographic fractionation assay of crude Anemonia sulcata homogenates with and without its [...] Read more.
Anemonia sulcata may be a source of marine natural products (MNPs) due to the antioxidant and antitumor activity of its crude homogenates shown in vitro in colon cancer cells. A bioguided chromatographic fractionation assay of crude Anemonia sulcata homogenates with and without its symbiont Symbiodinium was performed to characterize their bioactive composition and further determine their biological potential for the management of colorectal cancer (CRC). The 20% fractions retained the in vitro antioxidant activity previously reported for homogenates. As such, activation of antioxidant and detoxifying enzymes was also evaluated. The 40% fractions showed the greatest antiproliferative activity in T84 cells, synergistic effects with 5-fluoruracil and oxaliplatin, overexpression of apoptosis-related proteins, cytotoxicity on tumorspheres, and antiangiogenic activity. The predominantly polar lipids and toxins tentatively identified in the 20% and 40% fractions could be related to their biological activity in colon cancer cells although further characterizations of the active fractions are necessary to isolate and purify the bioactive compounds. Full article
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