Mitochondria-Targeted Approaches in Health and Disease 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2567
Special Issue Editor
Interests: mitochondria; bioenergetics; redox; reactive opxygen species; ATP synthase; respiration; phosphorylation; membranes; kidney; brain; cell death; protection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are one of the most intriguing intracellular elements. Apart from their great contribution to cellular bioenergetics, they perform various unique functions (both synthetic and regulatory). Now, it has become clear that mitochondrial fitness is a prerequisite of a healthy cell. Inherited or acquired mitochondrial dysfunction caused by changes in the genetic, lepidic, and proteinaceous content causing abnormal changes in structure and functions can be detrimental or even fatal for a cell. The intrinsic mechanism of mitochondrial quality control realizes the detection of unfit mitochondria or their elements with their elimination from the cell, ultimately clearing the system of abnormal mitochondrial structures. However, because of intrinsic and extrinsic challenges, this machinery misses mitochondrial defects, yielding the co-existence of normal and abnormal mitochondria within a single cell, which is a main index of diseases and aging. To avoid the unnecessary appearance of an unhealthy mitochondrial population in the cell when intrinsic mechanisms of reparation have partially or completely failed, various approaches have been successfully developed. The goal of the proposed Special Issue, Mitochondria-Targeted Approaches in Health and Disease, is to collect all of the possible methods of intervention into mitochondrial functioning, so as to prevent or repair unwanted changes in mitochondrial structure and function.
Prof. Dr. Dmitry B. Zorov
Guest Editor
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Keywords
- mitochondrial
- membrane potential
- DNA
- ATP synthase
- quality control
- mitophagy
- diseases targeting
- population analysis
- death
- cells
- signaling
- reactive oxygen species
- radicals
- damage protection
- structure
- functions
- respiratory chain
- complexes
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