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Molecular Research on Osteogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1307

Special Issue Editors


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Guest Editor
Department of Periodontology, Dental Research Administration, Tufts University School of Dental Medicine, Boston, MA 02111, USA
Interests: membranes/barries; blood-derived growth factors; guide bone regeneration; soft tissue regeneration; biomaterials; regenerative medicine; drug delivery systems
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Special Issue Information

Dear Colleagues,

In recent decades, there has been limited progress in expanding our understanding of osteogenesis, bone repair, and regenerative processes. Bone tissue, a complex mineralized structure, plays a crucial role in various biological activities. Comprising both organic and inorganic components unique to the human body, its regenerative mechanisms involve intricate physiological activities, primarily centered on the interplay between osteogenic and angiogenic events. These interactions drive bone formation and tissue rejuvenation. Vascular Endothelial Growth Factor (VEGF), a key player in angiogenesis, stimulates endothelial cell migration and proliferation, indirectly influencing osteogenesis by regulating osteogenic growth factors and engaging in paracrine signaling. Despite extensive research over the past two decades exploring bone defect repair processes and the development of biomaterials to facilitate these activities, there remains a significant gap in our understanding. The purpose of this Special Issue is to spotlight recent or emerging research updates on the biological aspects of osteogenesis, bone repair, and bone tissue regeneration. We welcome a variety of research approaches, including in vitro and in vivo studies, prospective trials, and retrospective cohort analyses, and strongly encourage the submission of review articles.

Dr. Roberto Sacco
Dr. Carlos Fernando Mourão
Guest Editors

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Keywords

  • osteogenesis
  • bone reconstruction
  • bone regeneration
  • bone disease

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Published Papers (1 paper)

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Research

15 pages, 10579 KiB  
Article
The Addition of Hydroxyapatite Nanoparticles on Implant Surfaces Modified by Zirconia Blasting and Acid Etching to Enhance Peri-Implant Bone Healing
by Ricardo Alves Toscano, Stéfany Barbosa, Larissa Gabriele Campos, Cecília Alves de Sousa, Eduardo Dallazen, Carlos Fernando Mourão, Jamil Awad Shibli, Edilson Ervolino, Leonardo P. Faverani and Wirley Goncalves Assunção
Int. J. Mol. Sci. 2024, 25(13), 7321; https://doi.org/10.3390/ijms25137321 - 3 Jul 2024
Cited by 1 | Viewed by 1016
Abstract
This study investigated the impact of adding hydroxyapatite nanoparticles to implant surfaces treated with zirconia blasting and acid etching (ZiHa), focusing on structural changes and bone healing parameters in low-density bone sites. The topographical characterization of titanium discs with a ZiHa surface and [...] Read more.
This study investigated the impact of adding hydroxyapatite nanoparticles to implant surfaces treated with zirconia blasting and acid etching (ZiHa), focusing on structural changes and bone healing parameters in low-density bone sites. The topographical characterization of titanium discs with a ZiHa surface and a commercially modified zirconia-blasted and acid-etched surface (Zi) was performed using scanning electron microscopy, profilometry, and surface-free energy. For the in vivo assessment, 22 female rats were ovariectomized and kept for 90 days, after which one implant from each group was randomly placed in each tibial metaphysis of the animals. Histological and immunohistochemical analyses were performed at 14 and 28 days postoperatively (decalcified lab processing), reverse torque testing was performed at 28 days, and histometry from calcified lab processing was performed at 60 days The group ZiHa promoted changes in surface morphology, forming evenly distributed pores. For bone healing, ZiHa showed a greater reverse torque, newly formed bone area, and bone/implant contact values compared to group Zi (p < 0.05; t-test). Qualitative histological and immunohistochemical analyses showed higher features of bone maturation for ZiHa on days 14 and 28. This preclinical study demonstrated that adding hydroxyapatite to zirconia-blasted and acid-etched surfaces enhanced peri-implant bone healing in ovariectomized rats. These findings support the potential for improving osseointegration of dental implants, especially in patients with compromised bone metabolism. Full article
(This article belongs to the Special Issue Molecular Research on Osteogenesis)
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