Liver Diseases: From Molecular Basis to Potential Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 6311
Special Issue Editor
Interests: iron; cytokines; protein expression; liver
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The liver is the largest organ of the body. Anatomically, it is located between the gastrointestinal tract and the systemic circulation. The liver is not only essential for the digestion of food stuffs introduced through the mouth and for the elimination of ingested toxicants and particulate matter which reaches the portal blood on the other side, but it also satisfies the need of such nutrients by distributing them to the rest of the body. A crucial function is the elimination of old erythrocytes and the delivery of the necessary components for replacement of the blood cells to the bone marrow. By producing the bulk of the plasma proteins, first albumin, but also those of the coagulation and complement system the liver is responsible for the corpuscolate and fluid components of the blood. Those proteins fulfill essential functions under normal, but more importantly under dangerous conditions, when the integrity of the liver itself, or more often when the integrity of extrahepatic tissues, is compromised. The Encyclopedia Britannica defines “disease, any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury”. The normal condition of the liver is still not well defined at the molecular level. This is, however, essential in order to recognize a disease as the consequence of the interruption of the different functions. A demarcation between disease and health may not always be apparent as the liver has a large functional reserve. This can, however, be overwhelmed in cases such as drug-induced liver damage, irradiation-induced liver fat accumulation, and acute or long-term damage or in some complications of pregnancy.
Topics of interest:
- Quality and quantity of lipids in different forms of steatosis in lean overweight and obese persons;
- Molecular consequences of lipids accumulation in the hepatocytes, e.g., bile production, protein synthesis including chemokines and cytokines;
- Mechanisms of hepatocellular damage induced by lipid accumulation;
- Consequences of steatosis for blood cell formation in the bone marrow;
- Consequences of steatosis for DNA-synthesis in hepatocellular nuclei;
- Ameiosis in the liver;
- Lipid overloading and mechanisms of volume change of the liver;
- Consequences of lipid overloading for extracellular matrix production and deposition;
- Liver and pregnancy: pathophysiology of HELLP-syndrome (coagulation, complement, production of blood cells);
- Molecular mechanisms of acute fatty liver and pregnancy;
- Molecular mechanisms of cholestatic disease in pregnancy;
- Irradiation effect on the liver and on liver cells;
- Irradiation and intracellular molecular changes;
- How can irradiation induce liver damage by regulating chemokine and cytokine-production.
Prof. Dr. Giuliano Ramadori
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
