Structure-Function Studies on Human Aromatase and Role in Pathologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 374
Special Issue Editors
Interests: aromatase; cytochromes P450; steroid hormones; endocrine disrupting chemicals
Special Issues, Collections and Topics in MDPI journals
2. Translational Hormone Research Program, Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland
Interests: cytochromes P450; steroid metabolism; aromatase; hormone dependent cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aromatase (CYP19A1), a cytochrome P450 enzyme responsible for the conversion of androgens to estrogens, is a key player in the endocrine system. As understanding the complex role of aromatase in various pathologies is crucial for the development of targeted therapies, research is ongoing to unravel the complex interplay between aromatase, estrogen and different pathologies.
Moreover, it is important to introduce new players into this picture, the so-called endocrine-disrupting chemicals (EDCs), exogenous substances interfering with the functioning of the endocrine system. Some EDCs can affect aromatase activity, leading to disturbances in hormonal balance and potentially causing a range of adverse health effects.
The aim of this special issue is to collect original papers and reviews that add new knowledge to the following potential topics:
- Structural and functional studies on aromatase
- Regulation of aromatase expression and activity by redox partners, regulatory proteins and post-translational modifications
- Role of aromatase in hormone-dependent pathologies
- Impact of EDCs on aromatase expression and activity
- Aromatase as a drug target and novel chemical leads for its inhibition.
Dr. Giovanna Di Nardo
Prof. Dr. Amit V. Pandey
Guest Editors
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Keywords
- aromatase
- CYP19A1
- endocrine system
- estrogens
- endocrine disrupting chemicals
- polymorphism
- redox partner interaction
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