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Factors Influencing Fascia: Which Alterations Could Underlie Pain?

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 2194

Special Issue Editor


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Guest Editor
Department of Neuroscience, University of Padova, 35122 Padova, Italy
Interests: fascia; pain; extracellular matrix; hyaluronan; collagen; sex hormones; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fascia is a complex, vital structure that responds to various kind of stimuli. The synthesis of the extracellular matrix can be stimulated and regulated by sex hormones, drugs, cannabinoids, mechanical stimulation and many other factors. At the same way, also temperature, pH, nutrition, aging and movement can alter the properties of the loose connective tissue, changing the gliding capacity of the fascial layers. Moreover, fasciae are hugely innervated, and play a role in proprioception and motor coordination (deep fasciae), thermoregulation, lymphatic and blood circulation and exteroception (superficial fasciae). The characterization of how various stimuli and conditions can modify the fascial tissue and its properties plays a crucial role in the analysis of the fasciae microanatomy and functionality and for the investigation of pathological phenomena. This Special Issue, “Factors Influencing Fascia: Which Alterations Could Underlie Pain?”, aims to publish the latest developments in the physiological and pathological alterations of fasciae. Original research, brief reports, and review articles are invited.

Dr. Caterina Fede
Guest Editor

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Keywords

  • superficial fascia
  • deep fascia
  • extracellular matrix
  • hyaluronan
  • collagen
  • innervation
  • pain perception

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Published Papers (1 paper)

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Research

11 pages, 2956 KiB  
Article
Detection of Mast Cells in Human Superficial Fascia
by Caterina Fede, Lucia Petrelli, Carmelo Pirri, Cesare Tiengo, Raffaele De Caro and Carla Stecco
Int. J. Mol. Sci. 2023, 24(14), 11599; https://doi.org/10.3390/ijms241411599 - 18 Jul 2023
Cited by 3 | Viewed by 1607
Abstract
The recent findings showed that the superficial fascia is a fibrous layer in the middle of hypodermis, richly innervated and vascularized, and more complex than so far demonstrated. This study showed the presence of mast cells in the superficial fascia of the human [...] Read more.
The recent findings showed that the superficial fascia is a fibrous layer in the middle of hypodermis, richly innervated and vascularized, and more complex than so far demonstrated. This study showed the presence of mast cells in the superficial fascia of the human abdomen wall of three adult volunteer patients (mean age 42 ± 4 years; 2 females, 1 male), by Toluidine Blue and Safranin-O stains and Transmission Electron Microscopy. Mast cells are distributed among the collagen bundles and the elastic fibers, near the vessels and close to the nerves supplying the tissue, with an average density of 20.4 ± 9.4/mm2. The demonstration of the presence of mast cells in the human superficial fascia highlights the possible involvement of the tissue in the inflammatory process, and in tissue healing and regeneration processes. A clear knowledge of this anatomical structure of the hypodermis is fundamental for a good comprehension of some fascial dysfunctions and for a better-targeted clinical practice. Full article
(This article belongs to the Special Issue Factors Influencing Fascia: Which Alterations Could Underlie Pain?)
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