The Role of Omics and Artificial Intelligence for the Personalized Management of Inflammatory and Neoplastic Digestive Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 9181
Special Issue Editors
2. Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: gastroenterology; oncology; digestive cancer; diverticular disease; cancer prevention; inflammatory bowel diseases; microbial communities; bioinformatics and computational biology
Special Issues, Collections and Topics in MDPI journals
2. Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’s disease; target therapy; biologic agents; small molecules; adhesion antagonists; anti-TNF; IBD vascular complications; stem-cells application in IBD; intestinal mucosal healing; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Interests: microbiomics; proteomics; metaproteomics; metabolomics; microbiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Omic data are multidimensional pieces of information that can play a crucial role in the field of personalized therapies and precision medicine. Indeed, the availability of huge data sets is not only exploitable in the context of experimental and research approaches, but also in the field of clinical medicine applications.
The generation, harmonization and integration of sets of clinical and laboratory omic data is extremely important in term of a patient-centered vision of healthcare, being used to produce advanced stratifications of disease phenotypes and new pathophysiological models.
Indeed, data-driven approaches allow us to investigate complex microbial communities or single-cell biochemical atlases. These provide new mechanistic pathological insights and new disease predictors or biomarkers, without any a priori restraint, but with an agnostic approach, hence opening new avenues for the current systems medicine.
The accessibility and interoperability of biobanks and digital biobanks allow for the exploitation of open source data, handled by powerful network management systems, a process which may be very useful for the community of omics scientists and clinicians. The impact of scientific consortia, national and international networks studyng omics data and artifical intelligence (A.I.) is progressively influencing the “real life”of the clinical management via the generation of clinical decision support system (CDSS) algorithms.
In this Special Issue, we welcome authors to submit original research and review articles, contributing to a better understanding of the following topics that include, but are not limited to:
- generation and analysis of the ecological and functional multidimentional data of microbial communities;
- role of artificial intelligence (A.I.) in training and validating clinical and laboratory big data for disease prediction models;
- applications of A.I. in inflammatory bowel diseases;
- applications of A.I. in neoplastic and preneoplastic digestive diseases.
Prof. Dr. Antonio Gasbarrini
Dr. Alfredo Papa
Prof. Dr. Lorenza Putignani
Guest Editors
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Keywords
- systems medicine
- big data
- data harmonization and integration
- artificial intelligence
- inflammatory digestive diseases
- neoplastic digestive diseases
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