Innate and Adaptive Immunity in COVID-19
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3112
Special Issue Editors
2. Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00161 Rome, Italy
Interests: tumor immunology; pathogenesis of immune-mediated diseases (infections and autoimmunity)
Special Issues, Collections and Topics in MDPI journals
Interests: B cells; B cell subpopulations; lymphokines; lymphomas; oncogenes; immunoglobulin genes
Special Issues, Collections and Topics in MDPI journals
2. Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA
3. The Transplantation Biology Program, University of Michigan, Ann Arbor, MI 48109, USA
Interests: the immunology and cell biology of transplantation; cancer and related fields
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In this Special Issue, we will consider the latest research on innate and adaptive immunology of SARS-CoV-2 and the associated disease COVID-19, in order to deeply understand the difference between protective immunity and immunopathology in patients with severe, moderated, mild, or asymptomatic COVID-19, as well as in recovered or vaccinated individuals. In this context, this Special Issue will enclose reports discussing human genetic susceptibility to infection, the role of innate immunity as the first line of defense against SARS-CoV-2, the kinetics of effector or memory B and T cell responses in providing durable immunity against new emerging variants, the interactions between innate and adaptive immunity addressed to limit viral entry and spread, and the dysfunctions of innate and/or adaptive immunity in contributing to COVID19 severity.
The scope of this Special Issue is, therefore, to provide insight into (i) the different facets of immunopathology supporting the phenomena associated with severe COVID-19, such as lymphopenia, impaired response to interferon, and “cytokine storm”; (ii) the immunoregulatory mechanisms addressed at controlling excessive inflammatory responses without excessively limiting the antiviral immune responses; and (iii) the differences in innate and adaptive immune responses between infected patients and vaccinated individuals, deciphering both immunopathology and protection signatures. This research will provide useful information to set up new therapeutic strategies and to develop new vaccines that prevent viral immune escape and the selection of new variants.
Prof. Dr. Vincenzo Barnaba
Prof. Dr. Manlio Ferrarini
Prof. Dr. Jeffrey L. Platt
Guest Editors
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Keywords
- COVID-19
- immunity
- immune escape
- immunopathology
- immunoregulatory mechanisms
- immunotherapy
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