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Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools

Special Issue Editor


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Guest Editor
1. Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 20123 Rome, Italy
2. Fondazione Policlinico Universitario IRCCS “A. Gemelli”, 00168 Rome, Italy
Interests: human proteomics; metabonomics; small molecules; mass spectrometry; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue aims is to collect contributions that underline the importance of mass spectrometry in qualitative-quantitative analysis for the identification of disease biomarkers and for the dosage of biomolecules and drugs, useful as a diagnostic and prognostic tool. The great advantage offered by this technology is given by the possibility of being able to correctly identify and quantify different endogenous and exogenous biomolecules, and generally coupled with liquid chromatography it provides a wide range of possibilities for personalized medicine.

In the clinical chemistry field, there is an increasingly greater demand for technology that serves as a reference point for various methods and which can satisfy analytical needs with adequate accuracy and precision.

Dr. Federica Iavarone
Guest Editor

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Keywords

  • mass spectrometry
  • quantitative analysis
  • biomarkers

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Published Papers (1 paper)

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Review

19 pages, 3819 KiB  
Review
Mass Spectrometry Advancements and Applications for Biomarker Discovery, Diagnostic Innovations, and Personalized Medicine
by Ahrum Son, Woojin Kim, Jongham Park, Yongho Park, Wonseok Lee, Sangwoon Lee and Hyunsoo Kim
Int. J. Mol. Sci. 2024, 25(18), 9880; https://doi.org/10.3390/ijms25189880 - 12 Sep 2024
Cited by 1 | Viewed by 3184
Abstract
Mass spectrometry (MS) has revolutionized clinical chemistry, offering unparalleled capabilities for biomolecule analysis. This review explores the growing significance of mass spectrometry (MS), particularly when coupled with liquid chromatography (LC), in identifying disease biomarkers and quantifying biomolecules for diagnostic and prognostic purposes. The [...] Read more.
Mass spectrometry (MS) has revolutionized clinical chemistry, offering unparalleled capabilities for biomolecule analysis. This review explores the growing significance of mass spectrometry (MS), particularly when coupled with liquid chromatography (LC), in identifying disease biomarkers and quantifying biomolecules for diagnostic and prognostic purposes. The unique advantages of MS in accurately identifying and quantifying diverse molecules have positioned it as a cornerstone in personalized-medicine advancement. MS-based technologies have transformed precision medicine, enabling a comprehensive understanding of disease mechanisms and patient-specific treatment responses. LC-MS has shown exceptional utility in analyzing complex biological matrices, while high-resolution MS has expanded analytical capabilities, allowing the detection of low-abundance molecules and the elucidation of complex biological pathways. The integration of MS with other techniques, such as ion mobility spectrometry, has opened new avenues for biomarker discovery and validation. As we progress toward precision medicine, MS-based technologies will be crucial in addressing the challenges of individualized patient care, driving innovations in disease diagnosis, prognosis, and treatment strategies. Full article
(This article belongs to the Special Issue Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools)
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