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Medical Applications for 3D Bioprinting 2.0
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Medical Applications for 3D Bioprinting 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 5590

Special Issue Editors

Dr. Isabel Andia

E-Mail Website
Guest Editor
Bioprinting Laboratory, Regenerative Therapies, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza Cruces 12, 48903 Barakaldo, Bizkaia, Spain
Interests: healing mechanisms; orthobiologics; sports injuries; regenerative medicine technologies; wound management
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giovanna Della Porta

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: drug delivery; micro/nano carriers; new technologies for drug carriers development; innovative drug carriers; biopolymers; liposomes; nanogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Bioprinting technologies have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials and are currently being used for the manufacture of tissue constructs in tissue engineering and regenerative medicine.

However, many challenging intricacies have to be met before bioprinting technologies achieve their full potential. Novel smart bioinks have to recreate complex tissues and the crosstalk between the different cell phenotypes; in addition, their attributes need to be tailored to the bioprinting modality.

The current Special Issue will cover a selection of articles that inform about novel bioink development, especially for bone, cartilage, tendon/ligament, muscle, and skin. Up-to-date reviews and original papers related to any aspect of medical applications (i.e., creating models for disease research, toxicity screening, functional drug evaluation, or translational clinical research) are welcome.

Dr. Isabel Andia
Prof. Dr. Giovanna Della Porta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • biopolymers
  • biomaterials
  • drug delivery
  • healing mechanisms
  • signaling proteins
  • biophysics

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Published Papers (2 papers)

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Research

14 pages, 4277 KiB  
Article
Release Kinetics and In Vitro Characterization of Sodium Percarbonate and Calcium Peroxide to Oxygenate Bioprinted Tissue Models
by Dongxu Ke, Carlos Kengla, Sang Jin Lee, James J. Yoo, Xuesong Zhu and Sean Vincent Murphy
Int. J. Mol. Sci. 2022, 23(12), 6842; https://doi.org/10.3390/ijms23126842 - 20 Jun 2022
Cited by 10 | Viewed by 2079
Abstract
Oxygen-generating materials have been used in several tissue engineering applications; however, their application as in situ oxygen supply within bioprinted constructs has not been deeply studied. In this study, two oxygen-generating materials, sodium percarbonate (SPO) and calcium peroxide (CPO), were studied for their [...] Read more.
Oxygen-generating materials have been used in several tissue engineering applications; however, their application as in situ oxygen supply within bioprinted constructs has not been deeply studied. In this study, two oxygen-generating materials, sodium percarbonate (SPO) and calcium peroxide (CPO), were studied for their oxygen release kinetics under a 0.1% O2 condition. In addition, a novel cell-culture-insert setup was used to evaluate the effects of SPO and CPO on the viability of skeletal muscle cells under the same hypoxic condition. Results showed that SPO had a burst oxygen release, while CPO had a more stable oxygen release than SPO. Both SPO and CPO reduced cell viability when used alone. The addition of catalase in SPO and CPO increased the oxygen release rate, as well as improving the viability of skeletal muscle cells; however, CPO still showed cytotoxicity with catalase. Additionally, the utilization of 1 mg/mL SPO and 20 U catalase in a hydrogel for bioprinting significantly enhanced the cell viability under the hypoxic condition. Moreover, bioprinted muscle constructs could further differentiate into elongated myotubes when transferring back to the normoxic condition. This work provides an excellent in vitro model to test oxygen-generating materials and further discover their applications in bioprinting, where they represent promising avenues to overcome the challenge of oxygen shortage in bioprinted constructs before their complete vascularization. Full article
(This article belongs to the Special Issue Medical Applications for 3D Bioprinting 2.0)
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19 pages, 8580 KiB  
Article
Wound-Microenvironment Engineering through Advanced-Dressing Bioprinting
by Cristina Del Amo, Xabier Fernández-San Argimiro, María Cascajo-Castresana, Arantza Perez-Valle, Iratxe Madarieta, Beatriz Olalde and Isabel Andia
Int. J. Mol. Sci. 2022, 23(5), 2836; https://doi.org/10.3390/ijms23052836 - 4 Mar 2022
Cited by 11 | Viewed by 2818
Abstract
In patients with comorbidities, a large number of wounds become chronic, representing an overwhelming economic burden for healthcare systems. Engineering the microenvironment is a paramount trend to activate cells and burst-healing mechanisms. The extrusion bioprinting of advanced dressings was performed with novel composite [...] Read more.
In patients with comorbidities, a large number of wounds become chronic, representing an overwhelming economic burden for healthcare systems. Engineering the microenvironment is a paramount trend to activate cells and burst-healing mechanisms. The extrusion bioprinting of advanced dressings was performed with novel composite bioinks made by blending adipose decellularized extracellular matrix with plasma and human dermal fibroblasts. Rheological and microstructural assessments of the composite hydrogels supported post-printing cell viability and proliferation over time. Embedded fibroblasts expressed steady concentrations of extracellular matrix proteins, including type 1, 3 and 4 collagens and fibronectin. ELISA assessments, multiplex protein arrays and ensuing bioinformatic analyses revealed paracrine activities corresponding to wound-healing activation through the modulation of inflammation and angiogenesis. The two modalities of advanced dressings, differing in platelet number, showed differences in the release of inflammatory and angiogenic cytokines, including interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF). The conditioned media stimulated human-dermal-cell proliferation over time. Our findings open the door to engineering the microenvironment as a strategy to enhance healing. Full article
(This article belongs to the Special Issue Medical Applications for 3D Bioprinting 2.0)
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