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Advances in Molecular Research and Treatment of Asthma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2455

Special Issue Editors


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Guest Editor
1. Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 89, 95123 Catania, Italy
2. Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97, 95123 Catania, Italy
Interests: tobacco harm reduction; reduction in exposure damage; electronic cigarettes; asthma; diabetes mellitus; cardiovascular disease; metabolic syndrome; emergency medicine; first aid

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Guest Editor
Respiratory Unit, A.O.U. Policlinico-Vittorio Emanuele, 95123 Catania, Italy
Interests: respiratory diseases; asthma; COPD; sleep medicine

Special Issue Information

Dear Colleagues, 

Asthma is a heterogeneous disorder affecting more than 300 million people worldwide. The management of asthma, particularly severe asthma, has profoundly changed in recent years as a consequence of the characterization of different endotypes, producing specific features in each patient. After nearly two decades since the approval of omalizumab for use in asthma, a number of novel biologics, mainly monoclonal antibodies such as anti-IL5, anti-IL5R and anti-IL4R, are now available for the management of severe asthma through the use of a personalised, pathway-specific approach. These drugs have completely changed patients’ lives, improving symptoms and exacerbations, sparing oral steroids and improving their quality of life. With this call, we wish to ask experts in the field to provide their contributions regarding the latest evidence on the pathogenesis and treatment of asthma. Specifically, we want to focus on asthma phenotypic clusters linked to different cellular pathways, the development of novel biomarkers, molecular mechanisms predisposing exacerbations, delineation of inflammatory pathways with omics analyses, genetic and environmental drivers, epigenetic mechanisms operating from childhood to adulthood, characterization of endotypes, implications for therapy and the role of biologics in specific targeted therapy. Finally, we want to highlight the role of long-lasting bronchodilators/anti-inflammatory drugs and their administration through novel and simpler inhalation ways.

Prof. Dr. Davide Campagna
Dr. Lucia Spicuzza
Guest Editors

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Keywords

  • management of asthma
  • monoclonal antibodies for asthma
  • asthma phenotypes
  • asthma inflammatory pathways
  • severe asthma treatments
  • asthma exacerbation

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Published Papers (1 paper)

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Review

31 pages, 1151 KiB  
Review
Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics
by Romana Barosova, Eva Baranovicova, Juliana Hanusrichterova and Daniela Mokra
Int. J. Mol. Sci. 2024, 25(1), 459; https://doi.org/10.3390/ijms25010459 - 29 Dec 2023
Cited by 2 | Viewed by 1708
Abstract
Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for [...] Read more.
Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In the diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on the metabolic alterations associated with human asthma. Further information is brought by metabolomic analysis of samples obtained from animal models. This article summarizes the current knowledge on metabolomic changes in human and animal studies of asthma and reveals that alterations in lipid metabolism, amino acid metabolism, purine metabolism, glycolysis and the tricarboxylic acid cycle found in the animal studies resemble, to a large extent, the changes found in human patients with asthma. The findings indicate that, despite the limitations of animal modeling in asthma, pre-clinical testing and metabolomic analysis of animal samples may, together with metabolomic analysis of human samples, contribute to a novel way of personalized treatment of asthma patients. Full article
(This article belongs to the Special Issue Advances in Molecular Research and Treatment of Asthma)
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