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Molecular Insights into Hair Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 5098

Special Issue Editor


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Guest Editor
EPIBIOTECH, Incheon, Republic of Korea
Interests: hair loss; skin; stem cells

Special Issue Information

Dear Colleagues,

As guest editor, I am pleased to introduce this Special Issue of IJMS titled "Molecular Insights into Hair Regeneration". Hair loss and its impact are pervasive challenges and have prompted a surge in scientific investigation into the molecular intricacies of hair growth and regeneration.

This Special Issue addresses the complex interplay of molecular mechanisms, genetic factors, and environmental influences that govern the intricate process of hair follicle development and regeneration. With the increasing demand for solutions to hair loss, various treatments have been sought, though comprehensive solutions are yet to be developed.

We invite authors to submit contributions to this Special Issue, including original research articles, reviews, commentaries, and perspectives, that contribute to unraveling the molecular mechanisms underlying hair regeneration. By advancing our collective understanding, we aim to open new avenues to therapeutic innovation for addressing the challenges of hair loss.

We look forward to receiving contributions from IJMS readers and highlighting diverse perspectives that contribute to the latest research and development in the field of hair regeneration.

Prof. Dr. Jong-Hyuk Sung
Guest Editor

Manuscript Submission Information

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Keywords

  • hair loss
  • androgenic alopecia
  • alopecia areata
  • cell therapy
  • antibody therapy

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Published Papers (3 papers)

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Research

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20 pages, 5385 KiB  
Article
Effects of Nannochloropsis salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth
by Ming Ying, Jialin Zhou, Zuye Zeng, Shuangfei Li and Xuewei Yang
Int. J. Mol. Sci. 2024, 25(15), 8231; https://doi.org/10.3390/ijms25158231 - 28 Jul 2024
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Abstract
The hair follicle is the basis of hair regeneration, and the dermal papilla is one of the most important structures in hair regeneration. New intervention and reversal strategies for hair loss may arise due to the prevention of oxidative stress. GC/MS analysis was [...] Read more.
The hair follicle is the basis of hair regeneration, and the dermal papilla is one of the most important structures in hair regeneration. New intervention and reversal strategies for hair loss may arise due to the prevention of oxidative stress. GC/MS analysis was used to determine the compounds contained in NSO. Then, NSO was applied to DPC for cell proliferation and oxidative stress experiments. RNA-seq was performed in cells treated with NSO and minoxidil. The quantitative real-time polymerase chain reaction (qRT-PCR) was applied to verify the gene expression. The effects of NSO on hair length, weight, the number and depth of hair follicles, and the dermal thickness were also studied. GC/MS analysis showed that the main components of NSO were eicosapentaenoic acid, palmitic acid, and linoleic acid. NSO promotes DPC proliferation and reduces H2O2-mediated oxidative damage. NSO can also activate hair growth-related pathways and upregulate antioxidant-related genes analyzed by gene profiling. The topical application of NSO significantly promotes hair growth and increases hair length and weight in mice. NSO extract promotes hair growth and effectively inhibits oxidative stress, which is beneficial for the prevention and treatment of hair loss. Full article
(This article belongs to the Special Issue Molecular Insights into Hair Regeneration)
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17 pages, 8717 KiB  
Article
Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia
by María Antonia Martínez-Pascual, Silvia Sacristán, Elena Toledano-Macías, Pablo Naranjo and María Luisa Hernández-Bule
Int. J. Mol. Sci. 2024, 25(14), 7865; https://doi.org/10.3390/ijms25147865 - 18 Jul 2024
Cited by 2 | Viewed by 1901
Abstract
Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence of the effectiveness [...] Read more.
Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence of the effectiveness of RF for alopecia, its effects at the tissue and cellular level have not been studied in detail. The objective of this study was to analyze ex vivo the potential effect of RF currents used in capacitive resistive electrical transfer (CRET) therapy on AGA. Hair follicles (HFs) were donated by patients with AGA and treated with CRET. AGA-HFs were exposed in vitro to intermittent 448 kHz electric current in subthermal conditions. Cell proliferation (Ki67), apoptosis (TUNEL assay), differentiation (β-catenin), integrity (collagen and MMP9), thickness of the epidermis surrounding HF, proportion of bulge cells and melanoblasts in AGA-HF were analyzed by immunohistochemistry. CRET increased proliferation and decreased death of different populations of AGA-HF cells. In addition, the melanoblasts increased in bulge and the epidermis surrounding the hair follicle thickened. These results support the effectiveness of RF-based therapies for the treatment of alopecia. However, clinical trials are necessary to know the true effectiveness of CRET therapy and other RF therapies for AGA treatment. Full article
(This article belongs to the Special Issue Molecular Insights into Hair Regeneration)
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Review

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24 pages, 2440 KiB  
Review
Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy
by Su-Eon Jin and Jong-Hyuk Sung
Int. J. Mol. Sci. 2024, 25(14), 7612; https://doi.org/10.3390/ijms25147612 - 11 Jul 2024
Viewed by 1852
Abstract
Therapeutic needs for hair loss are intended to find small interfering ribonucleic acid (siRNA) therapeutics for breakthrough. Since naked siRNA is restricted to meet a druggable target in clinic,, delivery systems are indispensable to overcome intrinsic and pathophysiological barriers, enhancing targetability and persistency [...] Read more.
Therapeutic needs for hair loss are intended to find small interfering ribonucleic acid (siRNA) therapeutics for breakthrough. Since naked siRNA is restricted to meet a druggable target in clinic,, delivery systems are indispensable to overcome intrinsic and pathophysiological barriers, enhancing targetability and persistency to ensure safety, efficacy, and effectiveness. Diverse carriers repurposed from small molecules to siRNA can be systematically or locally employed in hair loss therapy, followed by the adoption of new compositions associated with structural and environmental modification. The siRNA delivery systems have been extensively studied via conjugation or nanoparticle formulation to improve their fate in vitro and in vivo. In this review, we introduce clinically tunable siRNA delivery systems for hair loss based on design principles, after analyzing clinical trials in hair loss and currently approved siRNA therapeutics. We further discuss a strategic research framework for optimized siRNA delivery in hair loss from the scientific perspective of clinical translation. Full article
(This article belongs to the Special Issue Molecular Insights into Hair Regeneration)
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