The Application of Functional Biomaterials to Activate Induced Pluripotent Stem Cells in Tissue Engineering
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2233
Special Issue Editor
Special Issue Information
Dear Colleagues,
The induced pluripotent stem cell (iPSCs) is a promising patient-specific cell source for tissue engineering. To overcome the limitations associated with stability, efficiency, and in vivo adaptability of traditional iPSC culture protocols, biomaterials can play critical roles in the iPSC field not only via the integration of biomaterials with existing iPSC in vitro expansion and differentiation culture strategies, but also by facilitating efficient iPSC transplantation. So far, with multidisciplinary efforts from stem cell biologists, materials scientists, and engineers, developing well-defined biomaterial substrates has unfolded the possibility of modulating the epigenetic state of iPSCs through nanoscale topographical cues, mechanical dynamics, and novel targeting gene delivery technologies.
In this Special Issue, we welcome articles with a strong focus on biomaterial-based in vitro and/or in vivo activation of iPSC for expansion and differentiation applicable in regenerative medicine. We will also be pleased to include the review articles concerning the state of the art and novel concepts in biomaterials for next-generation iPSC transplantation strategies. The Special Issue will cover a wide spectrum of research subjects including:
- Novel biomaterial designs optimal for large-scale in vitro iPSC expansion and differentiation;
- Nanotopographic modifications of scaffolds and mechanism of iPSC response to surface cues;
- Intracellular delivery kinetics in reprogramming factor-loaded biomaterials;
- Extracellular matrix patterning for epigenetic regulation of iPSCs;
- Electrical/mechanical stimuli-based iPSC modulation;
- 3D bioprinting consisting of iPSC and biomaterials.
Dr. Jung-hyun Park
Guest Editor
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Keywords
- biomaterials
- induced pluripotent stem cell
- tissue engineering
- nanotechnology
- drug delivery system
- nano/microenvironment
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