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Latest Reviews in Molecular Nanoscience 2023

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4337

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Department of Pharmaceutical Sciences, College of Pharmacy, WSH, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA
Interests: nanomedicine; biophysics; DNA replication and recombination; protein-DNA interaction; chromatin structure and dynamics; Alzheimer's disease; Parkinson's disease; amyloid protein aggregation; protein misfolding; alpha-synuclein; beta amyloid; protein–protein interaction; computational modeling; nanoimaging; single-molecule biophysics; force spectroscopy; atomic force microscopy; AFM
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Special Issue Information

Dear Colleagues,

This Special Issue aims to collect high quality review papers in all the fields of Molecular Nanoscience. We encourage researchers from related fields to contribute review papers highlighting the latest developments in Molecular Nanoscience, or to invite relevant experts and colleagues to do so. Full length comprehensive reviews will be preferred. Topics include, without being limited to:

  • Nanoassemblies;
  • Nanomedicines;
  • Nanotechnology;
  • Nanosensors;
  • Nanocatalysts;
  • Nanocomposites;
  • Nanobots;
  • Nanomachines;
  • Single-molecule approaches;
  • Computational modeling of nanosystems.

Prof. Dr. Yuri Lyubchenko
Guest Editor

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Published Papers (1 paper)

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25 pages, 696 KiB  
Review
In Vitro Cell Transformation Assays: A Valuable Approach for Carcinogenic Potentiality Assessment of Nanomaterials
by Nivedita Chatterjee and Ernesto Alfaro-Moreno
Int. J. Mol. Sci. 2023, 24(9), 8219; https://doi.org/10.3390/ijms24098219 - 4 May 2023
Cited by 4 | Viewed by 3837
Abstract
This review explores the application of in vitro cell transformation assays (CTAs) as a screening platform to assess the carcinogenic potential of nanomaterials (NMs) resulting from continuously growing industrial production and use. The widespread application of NMs in various fields has raised concerns [...] Read more.
This review explores the application of in vitro cell transformation assays (CTAs) as a screening platform to assess the carcinogenic potential of nanomaterials (NMs) resulting from continuously growing industrial production and use. The widespread application of NMs in various fields has raised concerns about their potential adverse effects, necessitating safety evaluations, particularly in long-term continuous exposure scenarios. CTAs present a realistic screening platform for known and emerging NMs by examining their resemblance to the hallmark of malignancy, including high proliferation rates, loss of contact inhibition, the gain of anchorage-independent growth, cellular invasion, dysregulation of the cell cycle, apoptosis resistance, and ability to form tumors in experimental animals. Through the deliberate transformation of cells via chronic NM exposure, researchers can investigate the tumorigenic properties of NMs and the underlying mechanisms of cancer development. This article examines NM-induced cell transformation studies, focusing on identifying existing knowledge gaps. Specifically, it explores the physicochemical properties of NMs, experimental models, assays, dose and time requirements for cell transformation, and the underlying mechanisms of malignancy. Our review aims to advance understanding in this field and identify areas for further investigation. Full article
(This article belongs to the Special Issue Latest Reviews in Molecular Nanoscience 2023)
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