Natural Products in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 5418
Special Issue Editors
Interests: immunology; microbiology; nutrition; mucosal immunity; nutraceuticals; polyphenols; pathology; obesity; cytokines
Special Issues, Collections and Topics in MDPI journals
Interests: human microbiota; probiotics; H. pylori; SARS-CoV-2; oncogenesis; history of medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is the second leading cause of death in the world, especially in industrialised countries. Cancer development is a consequence of genetic, environmental and dietary factors. A condition of excessive food intake triggers inflammatory processes that can evolve into the development of diseases which, in turn, facilitate the onset of cancer such as colorectal, esophageal, pancreas and stomach whereas in the female the onset of breast, endometrial and ovarian cancer is more frequent. Overnutrition and lifestyle cause an alteration of metabolism due to an established inflammatory status. The immune system continuously exposed to endogenous and exogenous stimuli is responsible for the production of pro-inflammatory cytokines by both innate and adaptive immunity cells. These cytokines such as TNF-a, IL-1b and IFN-g lead to the activation of the NF-kb pathway, thus amplifying the inflammatory response. In addition, an excessive production of nitric oxide and reactive oxygen species is also observed.
In particular, the excessive intake of junk food and low physical activity facilitates the onset of cancer. However, malnutrition is also responsible for tumorigenesis and should be investigated. Finally, the presence of microrganisms and viruses also contributes to cancer development.
Natural products such as dietary fibre, polyhenols and polyunsaturated fatty acids may be useful in preventing the onset of cancer. In this special issue the mechanisms of action due to the intake of natural products and their potential beneficial effects on cancer prevention will be investigated.
Therefore, original article or review articles regarding the signalling pathways, molecular mechanisms and the involvement of immune system in prevention of cancer through intake of natural products are welcome.
Dr. Thea Magrone
Dr. Luigi Santacroce
Guest Editors
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Keywords
- natural products
- colorectal cancer
- gastric cancer
- microorganisms
- signalling and molecular mechanisms
- immune system
- cytokines
- overnutrition
- lifestyle
- gut microbiota
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