Cardiotoxicity of Anticancer Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7058
Special Issue Editors
Interests: intracellular signaling; mitochondrial function; endothelial function; beta adrenergic receptors; oxidative stress; inflammation; cardiotoxicity; molecular oncology
Special Issues, Collections and Topics in MDPI journals
Interests: adrenergic receptors; beta adrenergic receptors; cardiology; cardiovascular disease; endothelial cells; endothelium; heart failure; hypertension; signal transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The development of new drugs and innovative therapeutic strategies during the last decade has allowed patients to survive for longer following diagnosis of cancer than in the past. However, some anticancer drugs have cardiotoxic effects, which occur during or after treatment and can lead to the death of patients independently from the outcomes of oncologic therapy. Thus, the patients undergoing treatment with these drugs have a high risk of developing cardiovascular diseases and, consequently, to die from the side effects of the therapy rather than from the cancer. The discovery of the molecular mechanisms involved in cardiac responses to cardiotoxic drugs, which are still poorly known, represents the current goal of the cardio-oncology research aimed at preventing or treating cardiotoxicity. Over the years, this field of research has experienced progressively growing interest in identifying the molecular mechanisms underpinning the cardiotoxic effects of anticancer treatments, novel molecular targets to allow the design and development of novel biological therapeutic strategies, and early markers of cardiotoxicity toward preventing cardiac damage or to for promptly initiating effective therapy. Several targets involved in both the development of cardiovascular disease and cancer have been identified, including but not limited to GRKs, TLR, NFκB, and GPCR. Cardiomyocytes are generally the research target in these studies, but the functional contribution of non-myocyte cardiac cells is also receiving growing interest considering the functional crosstalk between the different types of cardiac cells. Among them, the influence of both resident and infiltrating immune cells as well as the contribution of fibroblasts and endothelial cells is fundamental in pathologic cardiac remodeling. This cellular crosstalk could be impaired by anticancer treatments, contributing to the exacerbation of cardiomyocyte damage. We welcome contributions that could increase the knowledge in the field and lead to ideas for the development of novel diagnostic and therapeutic strategies.
Dr. Daniela Sorriento
Prof. Dr. Guido Iaccarino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiotoxicity
- molecular mechanisms of cardiac damage
- intracellular signaling
- inflammatory pathways
- GPCR
- NFκB signaling
- GRKs
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
