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Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2475

Special Issue Editor


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Guest Editor
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
Interests: tendinopathy; tendon stem cells and their niches; tissue engineering and regenerative medicine; tendon and ligament healing

Special Issue Information

Dear Colleagues,

Tendinopathy is a multi-factorial tendon and joint disorder characterized by activity-related tendon pain, stiffness, and physical disability. The affected tendon degenerates and finally ruptures. Both conservative and surgical outcomes are unsatisfactory due to its unclear etiopathogenesis.

This Special Issue aims to encourage the study of the molecular mechanisms of tendinopathy and identify novel targets for its management. Both review and original articles focusing on the risk factors, molecular mechanisms, and novel treatment of tendinopathy are welcome. The roles of various risk factors, such as diabetes mellitus, obesity, dyslipidemia, and drugs, in increasing the susceptibility of tendinopathy development are of particular interest in this Special Issue. Factors affecting healing outcomes after tendon reattachment to bone and tendon repair after injury are within the scope of this Special Issue.

Studies on advanced molecular tools, such as various omics techniques, animal models, and new treatments, including cell-based therapy, drugs and biophysical therapies, and novel biomaterials, are encouraged to be submitted to this Special Issue.

Dr. Pauline Po Yee Lui 
Guest Editor

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Keywords

  • tendinopathy
  • tendon pain
  • stiffness
  • physical disability
  • etiopathogenesis
  • molecular mechanisms
  • tendon reattachment
  • tendon repair
  • advanced molecular tools
  • omics techniques
  • biophysical therapies
  • novel biomaterials

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Published Papers (2 papers)

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Research

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14 pages, 5145 KiB  
Article
Establishment of a Mouse Degenerative Model of Patellar Tendinopathy with Upregulation of Inflammation
by Pauline Po Yee Lui, Zuru Liang, Ri Min Tan and Patrick Shu Hang Yung
Int. J. Mol. Sci. 2024, 25(7), 3847; https://doi.org/10.3390/ijms25073847 - 29 Mar 2024
Cited by 1 | Viewed by 1142
Abstract
There is no mouse model of patellar tendinopathy. This study aimed to establish a mouse inflammatory and degenerative patellar tendon injury model, which will facilitate research on patellar tendinopathy using advanced molecular tools including transgenic models. Collagenase at different doses (low dose (LD), [...] Read more.
There is no mouse model of patellar tendinopathy. This study aimed to establish a mouse inflammatory and degenerative patellar tendon injury model, which will facilitate research on patellar tendinopathy using advanced molecular tools including transgenic models. Collagenase at different doses (low dose (LD), medium dose (MD), high dose (HD)) or saline was injected over the mouse patellar tendon. At weeks 1, 2, 4, and 8 post-injection, the tendons were harvested for histology and further examined by micro-computed tomography (microCT) imaging at week 8. The optimal dose group and the saline group were further evaluated by immunohistochemical staining, gait pattern, and biomechanical properties. The histopathological score increased dose-dependently post-collagenase injection. Ectopic mineralization was observed and increased with collagenase dose. The LD group was selected for further analysis. The expression of IL-10, TNF-α, and MMP-1 significantly increased post-injection. The changes of limb idleness index (ΔLII) compared to preinjury state were significantly higher, while the ultimate load, stiffness, ultimate stress, and maximum Young’s modulus were significantly lower in the LD group compared to the saline group. A mouse inflammatory degenerative model of patellar tendon injury resembling tendinopathy was established as indicated by the dose-dependent increase in tendon histopathology, ectopic calcification, decrease in biomechanical properties, and pain-associated gait changes. Full article
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Review

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36 pages, 1729 KiB  
Review
Advancements in Therapeutic Approaches for Degenerative Tendinopathy: Evaluating Efficacy and Challenges
by Vivek Kumar Morya, Hamzah Shahid, Jun Lang, Mi Kyung Kwak, Sin-Hye Park and Kyu-Cheol Noh
Int. J. Mol. Sci. 2024, 25(21), 11846; https://doi.org/10.3390/ijms252111846 - 4 Nov 2024
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Abstract
Degenerative tendinopathy results from the accumulation of minor injuries following unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is prolonged and varies between individuals, making it susceptible to reinjury. Moreover, treating chronic tendinopathy often requires expensive and extensive rehabilitation, [...] Read more.
Degenerative tendinopathy results from the accumulation of minor injuries following unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is prolonged and varies between individuals, making it susceptible to reinjury. Moreover, treating chronic tendinopathy often requires expensive and extensive rehabilitation, along with a variety of combined therapies to facilitate recovery. This condition significantly affects the quality of life of affected individuals, underscoring the urgent need for more efficient and cost-effective treatment options. Although traditional treatments have improved significantly and are being used as substitutes for surgical interventions, the findings have been inconsistent and conflicting. This review aims to clarify these issues by exploring the strengths and limitations of current treatments as well as recent innovations in managing various forms of degenerative tendinopathy. Full article
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