Translational Advances in Alzheimer's, Parkinson's, and Other Dementia: Molecular Mechanisms, Biomarkers, Diagnosis, and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1870
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite intense research into Alzheimer’s disease (AD) and other dementias, there is no drug that effectively intervenes in the pathogenesis of the disease. Dementia and other neurodegenerative diseases that affect memory, cognition, and behavior are public health priorities throughout the developed world. It is estimated that the number of people with dementia will double every 20 years. Most cases of AD are sporadic; less than 5% carry mutations affecting amyloid beta, and are early-onset familial AD that occur before the age of 65 years. By far the most pressing challenge is to distinguish the different forms of dementia or its early stages from the features of normal brain aging. In the case of vascular dementia, it may be possible to implement prevention strategies based on the closer and more accurate control of vascular risk factors. In the case of degenerative dementia, the exact molecular mechanisms leading to dementia are not well understood, although several mechanisms have been hypothesized at the cellular and neural network levels. Many research approaches may be applicable to the prevention and treatment of dementia, such as the identification of pathogenic compounds (toxins), the search for new targets, the development of new drugs through drug screening or drug design, cell or organelle therapy and device development (single/multiple targets), and other creative and innovative unconventional approaches.
This Special Issue will feature original research articles exploring the molecular mechanisms of dementia disorders from the above aspects, or comprehensive review articles covering these specific topics.
Dr. Avinash Gothwal
Guest Editor
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Keywords
- Alzheimer’s disease
- Parkinson’s disease
- dementia
- molecular mechanisms
- biomarkers
- diagnosis
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