ijms-logo

Journal Browser

Journal Browser

Molecular Research in Infective Mycobacteria

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1824

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, Via A. Ferrata 9, 27100 Pavia, Italy
Interests: bacterial biochemistry; enzymes; target identification; drug development; mycobacteria; infectious diseases; antimicrobial resistance; metabolites; computational approaches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research on mycobacteria is expanding thanks to the identification of emerging nontuberculous mycobacteria (NTM) pathogens like the opportunistic Mycobacterium abscessus complex, M. fortuitum, M. chelonae, or M. immunogenum. However, therapeutic approaches against NTM infections lack specificity, mainly relying on repurposed drugs originally developed for other pathogens such as M. tuberculosis or avium. In addition, mycobacteria are drawing particular attention for their peculiar features, such as their innate and acquired resistance to many drugs through a plethora of strategies.

This Special Issue aims to collect the most recent original papers and reviews on infectious mycobacteria, and will encompass well-known species like M. tuberculosis, avium and marium as well as the emerging NTM pathogens, with particular emphasis on molecular-level investigations.

Dr. Giovanni Stelitano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infections
  • mycobacteria
  • molecular biology
  • antimicrobials
  • bacteria biochemistry

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 1185 KiB  
Article
Retrospective Single Nucleotide Polymorphism Analysis of Host Resistance and Susceptibility to Ovine Johne’s Disease Using Restored FFPE DNA
by Amanda Kravitz, Mingsi Liao, Gota Morota, Ron Tyler, Rebecca Cockrum, B. Murali Manohar, B. Samuel Masilamoni Ronald, Michael T. Collins and Nammalwar Sriranganathan
Int. J. Mol. Sci. 2024, 25(14), 7748; https://doi.org/10.3390/ijms25147748 - 15 Jul 2024
Viewed by 1287
Abstract
Johne’s disease (JD), also known as paratuberculosis, is a chronic, untreatable gastroenteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection. Evidence for host genetic resistance to disease progression exists, although it is limited due to the extended incubation period (years) and [...] Read more.
Johne’s disease (JD), also known as paratuberculosis, is a chronic, untreatable gastroenteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection. Evidence for host genetic resistance to disease progression exists, although it is limited due to the extended incubation period (years) and diagnostic challenges. To overcome this, previously restored formalin-fixed paraffin embedded tissue (FFPE) DNA from archived FFPE tissue cassettes was utilized for a novel retrospective case-control genome-wide association study (GWAS) on ovine JD. Samples from known MAP-infected flocks with ante- and postmortem diagnostic data were used. Cases (N = 9) had evidence of tissue infection, compared to controls (N = 25) without evidence of tissue infection despite positive antemortem diagnostics. A genome-wide efficient mixed model analysis (GEMMA) to conduct a GWAS using restored FFPE DNA SNP results from the Illumina Ovine SNP50 Bead Chip, identified 10 SNPs reaching genome-wide significance of p < 1 × 10−6 on chromosomes 1, 3, 4, 24, and 26. Pathway analysis using PANTHER and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was completed on 45 genes found within 1 Mb of significant SNPs. Our work provides a framework for the novel use of archived FFPE tissues for animal genetic studies in complex diseases and further evidence for a genetic association in JD. Full article
(This article belongs to the Special Issue Molecular Research in Infective Mycobacteria)
Show Figures

Figure 1

Back to TopTop