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GPCR: Roles in Cell Development and Disease
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GPCR: Roles in Cell Development and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5372

Special Issue Editors

Dr. Rossella Miele

E-Mail Website
Guest Editor
Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy
Interests: G protein-coupled receptor; signal transduction; chemokines; protein-protein interactions; yeast genetic analysis; alternative splicing; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Dr. Roberta Lattanzi

E-Mail Website
Guest Editor
Department of Physiology and Pharmacology “Vittorio Erspamer”, University Sapienza, Rome, Italy
Interests: G protein-coupled receptor; chemokines; prokineticins; pain; neuroinflammation; in vivo and in vitro pharmacological analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

GPCRs include the most abundant group of human cell surface receptors and play key roles in several physiological processes, becoming an attractive drug target in human disease. The purpose of this Special Issue is to capture these new aspects of their activation and signaling during cell development, exploiting new knowledge about the structure of GPCRs given the direct link between the structure of a protein and its function.

Development includes morphogenetic processes that drive the formation of highly specialized organs. Once development is complete, some signaling pathways are maintained to ensure homeostasis of adult tissues.

Furthermore, the morphogenetic pathways vital to development are altered by invasive cells during tumor metastases and by a plethora of other diseases of genetic origin.

Dr. Rossella Miele
Dr. Roberta Lattanzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • GPCR
  • transcription factor
  • genetic diseases
  • micro RNA
  • prokineticins
  • development

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Published Papers (3 papers)

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Editorial

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2 pages, 159 KiB  
Editorial
Special Issue “GPCR: Roles in Cell Development and Disease”
by Roberta Lattanzi and Rossella Miele
Int. J. Mol. Sci. 2023, 24(9), 7943; https://doi.org/10.3390/ijms24097943 - 27 Apr 2023
Cited by 1 | Viewed by 1059
Abstract
We are pleased to present the following Special Issue of the International Journal of Molecular Sciences (IJMS), entitled “GPCR: Roles in Cell Development and Disease” [...] Full article
(This article belongs to the Special Issue GPCR: Roles in Cell Development and Disease)

Research

Jump to: Editorial

15 pages, 1315 KiB  
Article
Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes
by Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C. Miller and Paolo Annibale
Int. J. Mol. Sci. 2022, 23(18), 10405; https://doi.org/10.3390/ijms231810405 - 8 Sep 2022
Cited by 3 | Viewed by 2362
Abstract
The potential of human-induced pluripotent stem cells (hiPSCs) to be differentiated into cardiomyocytes (CMs) mimicking adult CMs functional morphology, marker genes and signaling characteristics has been investigated since over a decade. The evolution of the membrane localization of CM-specific G protein-coupled receptors throughout [...] Read more.
The potential of human-induced pluripotent stem cells (hiPSCs) to be differentiated into cardiomyocytes (CMs) mimicking adult CMs functional morphology, marker genes and signaling characteristics has been investigated since over a decade. The evolution of the membrane localization of CM-specific G protein-coupled receptors throughout differentiation has received, however, only limited attention to date. We employ here advanced fluorescent spectroscopy, namely linescan Fluorescence Correlation Spectroscopy (FCS), to observe how the plasma membrane abundance of the β1- and β2-adrenergic receptors (β1/2-ARs), labelled using a bright and photostable fluorescent antagonist, evolves during the long-term monolayer culture of hiPSC-derived CMs. We compare it to the kinetics of observed mRNA levels in wildtype (WT) hiPSCs and in two CRISPR/Cas9 knock-in clones. We conduct these observations against the backdrop of our recent report of cell-to-cell expression variability, as well as of the subcellular localization heterogeneity of β-ARs in adult CMs. Full article
(This article belongs to the Special Issue GPCR: Roles in Cell Development and Disease)
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9 pages, 1321 KiB  
Article
Arginine 125 Is an Essential Residue for the Function of MRAP2
by Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Roberta Lattanzi and Rossella Miele
Int. J. Mol. Sci. 2022, 23(17), 9853; https://doi.org/10.3390/ijms23179853 - 30 Aug 2022
Cited by 9 | Viewed by 1447
Abstract
MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G protein-coupled receptors, such as the prokineticin receptors, and regulates energy [...] Read more.
MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G protein-coupled receptors, such as the prokineticin receptors, and regulates energy expenditure and appetite. The aim of this work was to analyze the functional role of the specific arginine residue at position 125 of MRAP2, which affects protein conformation, dimer formation, and PKR2 binding. Results obtained with the MRAP2 mutants R125H and R125C, which are found in human patients with extreme obesity, and mouse MRAP2, in which arginine 125 is normally replaced by histidine, were compared with those obtained with human MRAP2. Understanding the mechanism by which MRAP2 regulates G protein-coupled receptors helps in elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs as specific targets of the MRAP2-PKR2 complex. Full article
(This article belongs to the Special Issue GPCR: Roles in Cell Development and Disease)
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