Advances in Sepsis: Pathogenesis, Biomarkers, Treatments and Prognosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 43
Special Issue Editor
Interests: sepsis; sepsis-induced cardiomyopathy; sepsis treatment; non-invasive ventilation; simulation; education
Special Issue Information
Dear Colleagues,
I am delighted to present this new IJMS Special Issue, collecting new developments in sepsis diagnosis and treatment.
In 2024, we are still discussing sepsis, even though we all know that it is not a single disease. Indeed, previous comorbidities, infection sources, and causative pathogens influence its development, evolution, and response to treatment, as well as the final prognosis. We need to improve our ability to characterize septic patients from several points of view.
First, we must learn to better recognize sepsis early to prompt the best treatment. New feasible and reliable biomarkers need to be validated with robust scientific evidence. It is also urgent to find the correct and meaningful application of new technologies for early bacterial identification. This would help us reduce the employment of empiric antibiotic treatments, a cornerstone in the fight against the growing spectrum of antimicrobial resistance. Similarly, we must overcome the “one-size-fits-all” approach that has guided the early resuscitation of septic patients until now. Meanwhile, an inadequate selection of study populations might explain the non-significant results obtained by several studies, which evaluated novel regimens of fluid administration or vasopressor dosing and timing without ascertaining whether the right patient was assigned to the right study arm. Improved characterization will translate into better prognostic assessment and early identification of patients at high risk of an adverse prognosis.
Importantly, contributions should focus on some molecular aspects but must not include only pure clinical research.
Dr. Francesca Innocenti
Guest Editor
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Keywords
- sepsis phenotypes
- hemodynamic stabilization
- fluids
- vasopressors
- diagnostic biomarkers
- tailored approach
- immune modulation
- immunomodulatory therapy
- prognostic stratification
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