Inflammation and Oxidative Stress in Xenobiotic-Induced Damage
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 7557
Special Issue Editors
Interests: pharmacology; inflammation; nitric oxide; macrophage; toxins; cell viability; apoptosis
Special Issues, Collections and Topics in MDPI journals
Interests: toxicology; endocrine disruptors; risk-to-benefit assessment
Special Issue Information
Dear Colleagues,
Inflammation and oxidative stress research cover all the way to medicine and health and disease research involving cell biology, biochemistry, chemistry, physiology and pathophysiology related mechanisms. Inflammation and oxidative stress are closely related in all these processes considering that one of which can be easily induced by another and, when not properly regulated, contributes to the development of many diseases that collectively represent the leading causes of disability and mortality worldwide Thus, both processes are simultaneously found in many, often chronic, pathological conditions (e.g. neurodegenerative diseases, cardiovascular diseases, diabetes, chronic kidney disease, liver disease, cancer, aging). Many factors are recognized as “triggering events” for chronic inflammation and oxidative stress such as xenobiotics.
Xenobiotics (e.g. drugs, dietary compounds, environmental chemicals and pollutants) can induce inflammation by a variety of different mechanisms often resulting in cell injury, degeneration and/or necrosis, either directly or indirectly, by parent or metabolite. Importantly, xenobiotics-dependent effects have significant relevance in food safety, considering that exposure of the general population to most of them occurs mainly by food. Xenobiotics may also activate inflammatory/immune cells to release inflammatory mediators in nonspecific ways, or by stimulating a specific immune response. Moreover, certain xenobiotics and/or their metabolites can also directly mediate the formation of reactive oxygen species damaging biomolecules and/or affecting signaling pathways.
The aim of this Special Issue is to provide an updated point of view about the relationship between inflammation and/or oxidative stress-related response and modulation by xenobiotics. In addition, contributes focused on bioactives able to counteract xenobiotics-induced inflammation and oxidative stress will be also considered.
Dr. Stefania Marzocco
Dr. Stefano Lorenzetti
Guest Editors
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Keywords
- inflammation
- oxidative stress
- chronic diseases
- xenobiotics
- bioactives
- pollutants
- endocrine disruptors
- drugs
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