New Research Insights in Cystic Fibrosis and CFTR-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 December 2024 | Viewed by 143
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cystic fibrosis (CF) is caused by the congenital loss of function of the CF transmembrane conductance regulator (CFTR), a cAMP-regulated anion channel expressing at the plasma membrane of epithelial cells. Dysregulated CFTR function caused by genetic and/or environmental stresses can participate in the pathogenesis of diseases, including chronic obstructive pulmonary disease (COPD) and bronchiectasis. The landscape of CF has changed significantly over the past 30 years, since the identification of the CFTR gene and the advent of CFTR modulating drugs. Current research aims to improve our understanding of disease pathogenesis in the CFTR modulator era. This includes new insights into the direct and indirect influences of CFTR modulation on the airway milieu, including resident pathogens, inflammation, and inflammatory cell function.
This Special Issue on “New Research Insights in Cystic Fibrosis and CFTR-Related Diseases” will gather reviews and original articles that provide novel insights into the immune landscape of CFTR-related diseases, as well as reporting on novel therapeutic approaches at the basic, translational, and clinical levels. Biomolecular studies and clinical studies with biomolecular components that provide expert insights and perspectives on advances in the field are welcome.
Dr. Judith A. Coppinger
Guest Editor
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Keywords
- cystic fibrosis
- CFTR related diseases
- COPD
- immune cells
- extracellular vesicles
- neutrophils
- therapeutics
- biomarkers
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