Cellular Senescence and the Senescence-Associated Secretory Phenotype (SASP) in Age-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 231
Special Issue Editor
Interests: pathophysiology; inflammation; cell biology; toxicology; neurodegeneration; COPD
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular senescence, a state of irreversible cell cycle arrest, plays a crucial role in the pathogenesis of various age-related diseases. The senescence-associated secretory phenotype (SASP), a collection of pro-inflammatory cytokines, chemokines, and matrix-remodeling proteins, is a key mediator of the detrimental effects of senescent cells.
This Special Issue aims to explore the mechanisms by which cellular senescence and SASPs contribute to the development and progression of age-related diseases, such as atherosclerosis, chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), osteoarthritis (OA), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and cancer, among others.
This Special Issue seeks to bridge the gaps between cellular aging mechanisms and clinical manifestations, fostering advancements in diagnosis, treatment, and prevention strategies. Contributions from leading researchers will explore molecular pathways, identify biomarkers, and propose therapeutic targets, offering new insights into the complex interplay between aging cells and disease progression. We invite submissions of original research articles, reviews, and perspectives that investigate the role of senescence and SASPs in these diseases, as well as potential therapeutic interventions targeting senescent cells and their secretory phenotype.
Understanding the complex interplay between cellular senescence, SASPs, and age-related diseases will be crucial for developing novel strategies in order to promote healthier aging.
Dr. Jordi Olloquequi
Guest Editor
Manuscript Submission Information
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Keywords
- cellular senescence
- senescence-associated secretory phenotype (SASP)
- age-related diseases
- atherosclerosis
- chronic obstructive pulmonary disease (COPD)
- type 2 diabetes mellitus (T2DM)
- non-alcoholic fatty liver disease (NAFLD)
- Alzheimer’s disease (AD)
- inflammation
- therapeutic targets
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