The Molecular Basis of Vascular Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 175
Special Issue Editor
Interests: endothelial dysfunction; microcirculation; macrocirculation; diabetes mellitus; cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vascular pathologies result from intricate interactions between multiple molecular mechanisms that culminate in the impairment and dysfunction of blood vessels. These changes occur in the endothelium, vascular smooth muscle, and extracellular matrix, as well as the immune and coagulation systems. Factors such as hypertension, hyperglycemia, high cholesterol, and smoking contribute to endothelial dysfunction, which results in increased vessel wall permeability. This facilitates the passage of lipids and other substances, initiating inflammatory processes. Pro-inflammatory cytokines and immune cells, including macrophages and T lymphocytes, drive the inflammatory process in blood vessel walls. These cells and factors can result in further vascular damage, increased proliferative processes, and the activation of smooth muscle cells, contributing to structural changes in the vessel walls. Similarly, oxidative stress plays a pivotal role in the progression of numerous vascular pathologies. This phenomenon stems from the excessive production of reactive oxygen species, which directly cause damage to the endothelium, ultimately leading to the formation of plaques that impede blood flow. Abnormal activation of the coagulation cascade can lead to the formation of clots, which may result in myocardial infarction, stroke, or pulmonary embolism.
All of the aforementioned processes contribute to the development and progression of vascular disease. A comprehensive understanding of these mechanisms is vital for the development of effective therapeutic strategies that could prevent these diseases or slow their progression.
This Special Issue of the International Journal of Molecular Sciences details the latest research on the molecular bases, early diagnosis, and treatment of vascular pathology. Titled “The Molecular Basis of Vascular Pathology”, this Special Issue welcomes in vitro and in vivo studies, as well as original research and reviews.
Dr. Jolanta Neubauer-Geryk
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- vascular pathologies
- blood vessels
- dysfunction
- vascular damage
- blood flow
- biomarkers
- biomolecules
- cytokines
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
