Mitochondrial Biogenesis and Metabolism in Gastrointestinal System Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5608
Special Issue Editors
Interests: Mitochondria; Bioenergetics; PGC-1s; Oxidative Phosphorylation; Cellular respiration; Cytochrome c Oxidase; Metabolic flux control; Cancer; Neurodegenerative diseases; Reactive Oxygen Species; Oxidative stress; Mitochondrial diseases; Aging; Antibiotics
Special Issues, Collections and Topics in MDPI journals
Interests: metabolism; mitochondria; lipid metabolism; reactive oxygen species; colorectal cancer; hepatocellular carcinoma; liver diseases; metabolic diseases; gut-liver axis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are at the core of multiple pathways within the cell. These organelles are fundamental in the coordination of cellular metabolism, stress response, apoptosis as well as immunity. Besides their central role in aerobic energy production, mitochondria are directly involved in several signal transduction pathways, which altogether act to determine cell fate and homeostasis. Alterations in mitochondrial biogenesis and metabolism contribute to the onset and progression of several pathologies. The gastrointestinal system occupies a central position in our body, regulating nutrients disposal, offering a first line of protection against pathogens and harbouring a microbial community, which has gained a lot of attention in the last years. Mitochondrial functions are essential to fulfil the great variety of aspects necessary to maintain an healthy gastrointestinal system. Perturbations of mitochondrial biogenesis and metabolism have been associated with a multitude of gastrointestinal disorders, including cancer, metabolic and inflammatory diseases. This Special Issue of IJMS will cover peculiar aspects of mitochondrial biogenesis and metabolism in relation to the gastrointestinal pathophysiology.
Prof. Dr. Gaetano Villani
Dr. Elena Piccinin
Guest Editors
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Keywords
- Mitochondria
- Energy homeostasis
- Metabolic regulations
- Gastrointestinal system
- Cancer
- Metabolic Diseases
- Microbiota
- Immunity
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