Molecular Research in Glioblastoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 284
Special Issue Editor
Interests: neuroscience; neuroinflammation; Alzheimer's disease; ELA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glioblastoma, from the neuroglial stem or progenitor cells in brain or spinal cord, can be classified by grade describing their level of abnormality on a scale from I to IV or according to their growth rate, being low, medium and high grade. In this type of tumors, glioblastoma is known to be the most common and aggressive tumor among adults (±90%), being the most malignant possible form of astrocytoma (Grade IV). The main characteristics respect others are the necrosis presence and tumor angiogenesis. On the other hand, anaplastic astrocytoma grade III, less extent than glioblastoma, is characterized by diffuse infiltration inside the neoplasm, nuclear atypia and mitotic activity confirming an anaplasia with an increase in growth rate compared to grade I and II gliomas. In addition, atypical oligodendroglioma (grade II) and anaplastic oligodendroglioma (grade III) exist. Neuroblastoma (from immature nerve cells) is produced from neural crest cells, so tumors can develop anywhere in the sympathetic nervous system. Finally, regarding grade I and II gliomas, both refers to benign tumors diagnosed. Grade I is exclusive detected in childhood and grade II gliomas require follow-up to prevent the tumor from appearing abnormally. This issue is focus in risks, complications and treatment options.
Dr. Soraya L. Valles
Guest Editor
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Keywords
- glioblastoma
- biomarker
- drug treatment
- genetics
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