Roles and Mechanisms of Non-Coding RNAs in Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 25 March 2025 | Viewed by 59
Special Issue Editor
Interests: hormone-dependent cancer, tumors of the breast, ovary and endometrium, estrogen receptor signaling, estrogen receptor, G-protein coupled estrogen receptor 1, transcriptome analysis
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Special Issue Information
Dear Colleagues,
Breast cancer in women is the second most common cancer and the fifth leading cause of cancer death worldwide. It has been demonstrated that non-coding RNAs (ncRNAs) representing the vast majority of the transcriptome are involved in the development and progression of breast cancer. Given the sheer amount of different ncRNA molecules and the complexity of their interactions, further studies are necessary to improve the understanding of their roles in breast cancer and to elucidate underlying molecular mechanisms. NcRNAs are not only important biomarkers in breast cancer but are considered as promising targets in breast cancer therapy. NcRNAs like miRNAs, lncRNAs, circRNAs, or piRNAs have been shown to regulate cancer-related genes by different mechanisms, either as cellular ncRNAs acting in an autocrine manner or in an endocrine manner transported by the bloodstream when protected by protein binding or by packing into exosomes.
This Special Issue of IJMS is calling for original work or comprehensive review articles on the role and mechanisms of ncRNAs in breast cancer. Original reports are welcome elucidating the role of single miRNAs, lncRNAs, circRNAs, or piRNAs with identification of specific mRNA targets linked to breast cancer tumorigenesis. Alternatively, studies identifying whole ncRNA sets working cooperatively to enhance or inhibit breast cancer growth are welcome. Of special interest are also circRNAs or exosome-packed ncRNAs, which have turned out to have high stability in the bloodstream, making them versatile non-invasive biomarkers. Finally, any specific strategy targeting oncogenic ncRNAs to inhibit breast cancer progression will be of great interest.
Prof. Dr. Oliver Treeck
Guest Editor
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Keywords
- breast cancer
- NcRNA
- MmiRNA
- LncRNA
- CircRNA
- PiRNA
- exosome-packed ncRNA
- role and mechanisms of ncRNA in breast cancer tissue or cell lines
- modulation of ncRNA levels by knock-out or knock-down approaches
- effects on breast cancer cell proliferation, invasion, or apoptosis
- identification of BC-relevant ncRNA–mRNA networks
- targeting ncRNAs with potential clinical implications
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