Pathophysiology of Neuropsychiatric Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 16053
Special Issue Editors
Interests: mood disorder; bipolar disorder; depression; psychopharmacology; clinical trial
Special Issue Information
Dear Colleagues,
Neuropsychiatric disorders comprise a wide range of disorders. None of them are single homogenous disorders, but rather are complex, heterogeneous disorders resulting from the interaction of various factors, including genetic, neurological, physical, and environmental. As a result, past research inevitably focused on investigating their pathophysiology by understanding symptomatic presentations such as clinical signs and symptoms of different disorders. However, with the rise of predictive, preventive, and personalized medicine, increasing studies emphasize the importance of biomarkers in the diagnosis and treatment of neuropsychiatric disorders. Recent advancements in molecular, biological, genetic, and neuroimaging techniques and analyses have also led to a much better understanding of their pathophysiology.
In accordance with these innovative translational researches and technologies, the brain–gut–microbiome theory is receiving increasing attention regarding important causative factors of various neuropsychiatric disorders. Correlation among depression, physical weakness evidenced by lowered muscle mass, and cognitive change highlight the importance of correlation among emotion, brain, and body. The medications for diabetes are now being tested for depression, so we must understand the role of insulin in mood disorders. The impact of neuro-inflammation and glucocorticoid receptors, which has been the important focus for decades, have recently been investigated using novel approaches such as epigenetics and mass data from nation-wide cohort studies. The classical interests including serotonin dysfunction correlated with evoked potential, circadian rhythm associated with mood disorder, and the neurophysiology of suicide have also been updated, needing comprehensive discussion.
In this Special Issue of IJMS, the focus will be on the pathophysiology of neuropsychiatric disease by considering the novel biomarkers of mood and geriatric disorders.
Dr. Won-Myong Bahk
Prof. Dr. Young Sup Woo
Guest Editors
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Keywords
- mood disorders
- neurophysiology
- cognition
- brain reserve
- circadian rhythm
- inflammation
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