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Pancreatic Cancer: Molecular Mechanisms and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 808

Special Issue Editor


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Guest Editor
Department of Biology, University of Pisa, 56123 Pisa, Italy
Interests: genetic; genetic epidemiology; cancer genetics; pancreatic cancer; epidemiology; mendelian randomization; polygenic score

Special Issue Information

Dear Colleagues,

Pancreatic cancer is a relatively rare and lethal disease. It has a complex nature, and multiple risk factors have been identified through epidemiological studies, but to better understand the molecular causes of this disease, molecular profiling is essential. This Special Issue aims to explore the latest discoveries in the field of molecular analysis of pancreatic cancer, with particular attention to new therapeutic perspectives, diagnostic and prognostic biomarkers, and innovations in understanding the molecular mechanisms underlying the pathogenesis and progression of the disease.

With the abundance of available novel data, new predictive models such as polygenic scores and Mendelian randomization analyses have been developed, which can open doors to the use of artificial intelligence. This state-of-the-art technology can enable the early detection and diagnosis of cancer, personalized treatment, and improved clinical management for cancer patients, leading to better clinical outcomes in the near future.

We cordially invite scientists working on pancreatic cancer and molecular oncology to contribute to this Special Issue.

Dr. Manuel Gentiluomo
Guest Editor

Manuscript Submission Information

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Keywords

  • pancreatic cancer
  • genetic
  • molecular profiling
  • biomarkers
  • predictive models
  • sequencing
  • modeling
  • polygenic score
  • mendelian randomization
  • machine learning
  • survival
  • therapy responses

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Published Papers (1 paper)

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Review

17 pages, 585 KiB  
Review
Select Endocrine Disorders and Exosomes in Early PDAC Diagnosis
by Barbara Wlodarczyk, Lukasz Durko, Konrad Walczak, Renata Talar-Wojnarowska and Ewa Malecka-Wojciesko
Int. J. Mol. Sci. 2024, 25(22), 12159; https://doi.org/10.3390/ijms252212159 - 13 Nov 2024
Viewed by 480
Abstract
Disturbances in carbohydrate metabolism are suggested to be the early symptoms of pancreatic ductal adenocarcinoma (PDAC). The accumulated data suggests that endocrine function-related biomarkers may represent a breakthrough in the early detection of PDAC. Factors which may predispose one to the development of [...] Read more.
Disturbances in carbohydrate metabolism are suggested to be the early symptoms of pancreatic ductal adenocarcinoma (PDAC). The accumulated data suggests that endocrine function-related biomarkers may represent a breakthrough in the early detection of PDAC. Factors which may predispose one to the development of PDAC are insulin resistance and hyperinsulinemia. Elevated insulin levels induce the onset of carcinogenesis by altering the differentiation and function of islet cells through stimulating growth factors, including insulin-like growth factors (IGFs). Impaired β cell function, along with the impact of PDAC-released factors (e.g., adrenomedullin (ADM), IGF-1, and macrophage inhibitory factor (MIF) on pancreatic islets, may contribute to the induction of diabetes associated with PDAC. Recently, exosomes have attracted worldwide attention due to their role in varied features of cell function, particularly in cancer progression. Exosomes comprise of small extracellular vesicles produced by almost all cells. These vesicles contain a vast array of biomolecules, including proteins and microRNAs. Exosomes participate in cancer growth and promote angiogenesis. They promote tumorigenesis and metastasis, and are associated with the acquisition of cancer cells resistant to chemotherapy. Data have been accumulating recently on the role of exosomes in the rapid recognition, prognosis and potential therapy of pancreatic cancer. Full article
(This article belongs to the Special Issue Pancreatic Cancer: Molecular Mechanisms and Therapeutic Strategies)
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