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Advanced Research of Mitochondria-Targeted Antioxidants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1247

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Guest Editor
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia
Interests: MDR pumps; antioxidants; antibiotics
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Special Issue Information

Dear Colleagues,

Mitochondria-targeted antioxidants are promising drug agents. They are involved in both anti-inflammatory and anti-cancer processes in eukaryotes, and have antibacterial and antifungal properties. In addition, they are used for the targeted delivery of drugs to the mitochondria, which opens up new prospects for the use of mitochondria-targeted antioxidants in various fields of medicine. We look forward to receiving articles on anti-inflammatory and anti-cancer activities from experts in biochemistry, cell biology, mycology, immunology, and bioenergetics. We also expect to receive articles from experts in the field of anti-aging. Potential topics include, but are not limited to: new mitochondria-targeted antioxidants; new properties of mitochondria-targeted antioxidants; the penetration of mitochondria-targeted antioxidants to cells; mitochondria-targeted antioxidants as anti-aging agents; mitochondria-targeted antioxidants as anti-cancer agents; mitochondria-targeted antioxidants as anti-inflammatory agents; mitochondria-targeted antioxidants as anti-fungal agents; mitochondria-targeted antioxidants as anti-bacterial agents; mitochondria-targeted antioxidants as anti-biofilm agents; and mitochondria-targeted antioxidants as vectors for drug delivery.

Dr. Pavel A. Nazarov
Guest Editor

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Keywords

  • antioxidants
  • mitochondria
  • biofilm
  • bacteria
  • yeast
  • aging
  • tumor
  • inflammation
  • bioenergetics
  • OXPHOS
  • metabolism

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Published Papers (1 paper)

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Research

14 pages, 2632 KiB  
Article
Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents
by Pavel A. Nazarov, Vladislav S. Maximov, Alexander M. Firsov, Marina V. Karakozova, Veronika Panfilova, Elena A. Kotova, Maxim V. Skulachev and Yuri N. Antonenko
Int. J. Mol. Sci. 2024, 25(11), 6137; https://doi.org/10.3390/ijms25116137 - 2 Jun 2024
Viewed by 794
Abstract
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are MitoQ and SkQ1, with its fluorescent rhodamine analog SkQR1, a [...] Read more.
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are MitoQ and SkQ1, with its fluorescent rhodamine analog SkQR1, a decyl ester of rhodamine 19 carrying plastoquinone. In the present work, we observed a pronounced antibacterial action of SkQR1 against Gram-positive bacteria, but virtually no effect on Gram-negative bacteria. The MDR pump AcrAB-TolC, known to expel SkQ1, did not recognize and did not pump out SkQR1 and dodecyl ester of rhodamine 19 (C12R1). Rhodamine 19 butyl (C4R1) and ethyl (C2R1) esters more effectively suppressed the growth of ΔtolC Escherichia coli, but lost their potency with the wild-type E. coli pumping them out. The mechanism of the antibacterial action of SkQR1 may differ from that of SkQ1. The rhodamine derivatives also proved to be effective antibacterial agents against various Gram-positive species, including Staphylococcus aureus and Mycobacterium smegmatis. By using fluorescence correlation spectroscopy and fluorescence microscopy, SkQR1 was shown to accumulate in the bacterial membrane. Thus, the presentation of SkQR1 as a fluorescent analogue of SkQ1 and its use for visualization should be performed with caution. Full article
(This article belongs to the Special Issue Advanced Research of Mitochondria-Targeted Antioxidants)
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