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Molecular Aspects of Bacterial Infection

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 965

Special Issue Editor


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Guest Editor
Department of Biological Science, California State University Fullerton, 800 N State College Blvd, Fullerton, CA 92831, USA
Interests: mechanisms of antibiotic resistance; bacterial pathogenesis; dissemination and evolution of pathogens; morbidity and mortality of bacterial infections; molecular mechanism of virulence; bacterial evolution
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Special Issue Information

Dear Colleagues,

This Special Issue on “Molecular Aspects of Bacterial Infection” aims to highlight the latest advances in understanding bacterial pathogenesis, host–pathogen interactions, and antimicrobial resistance mechanisms. As bacterial infections continue to pose significant global health challenges, research efforts focused on elucidating molecular pathways and identifying novel therapeutic strategies are crucial. This issue invites contributions that explore bacterial virulence factors, biofilm formation, resistance gene dissemination, and innovative treatment approaches, such as antimicrobial peptides and bacteriophages. By bringing together cutting-edge research, we hope to contribute to the development of more effective interventions and diagnostics for combating infectious diseases.

Leading by Dr. María Soledad Ramírez and assisting by our Topical Advisory Panel Member Dr. German Matias Traglia (Universidad de la República), this Special Issue aims to explore the intricate molecular mechanisms underlying bacterial infections, with a specific focus on antibiotic resistance. The issue will cover the following themes:

  • Mechanisms of Antibiotic Resistance;
  • Resistance Gene Dissemination;
  • Evolution of Resistant Strains;
  • Impact on Morbidity and Mortality;
  • Bacterial Virulence and Pathogenicity;
  • Innovative Treatment Strategies.

We invite researchers to submit original research, reviews, and case studies that align with these topics, contributing to the broader understanding of bacterial infections and resistance. Our goal is to foster a comprehensive discussion on combating bacterial pathogens through both molecular insights and clinical applications.

Prof. Dr. María Soledad Ramírez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial pathogenesis
  • antimicrobial resistance
  • molecular mechanism of host-pathogen interaction
  • biofilm
  • infectious diseases

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Published Papers (1 paper)

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Research

13 pages, 5902 KiB  
Article
Insights into Acinetobacter baumannii AMA205’s Unprecedented Antibiotic Resistance
by German Matias Traglia, Fernando Pasteran, Samyar Moheb, Usman Akhtar, Sebastian Gonzalez, Carolina Maldonado, Nicholas Furtado, Ahmed Mohamed, Jenny Escalante, Marisel R. Tuttobene, Araceli Quillen, Claudia Fontan, Ezequiel Albornoz, Alejandra Corso, Robert A. Bonomo, Gauri G. Rao, Marcelo E. Tolmasky and Maria Soledad Ramirez
Int. J. Mol. Sci. 2024, 25(21), 11424; https://doi.org/10.3390/ijms252111424 - 24 Oct 2024
Viewed by 720
Abstract
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. [...] Read more.
The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. The A. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain’s antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii’s ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains. Full article
(This article belongs to the Special Issue Molecular Aspects of Bacterial Infection)
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