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Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 389

Special Issue Editor


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Guest Editor
Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 970, Taiwan
Interests: biochemistry; genetics and molecular biology; medicine immunology; microbiology; agricultural and biological sciences; environmental science; pharmacology

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to explore the intricate relationship between the circulatory system, coagulation abnormalities and their collective impact on the progression and outcome of infectious diseases. We seek to understand how disruptions in blood flow and clotting mechanisms contribute to the pathophysiology of infections, with an emphasis on identifying potential therapeutic targets and prognostic markers.

This Special Issue will cover a range of topics, including, but not limited to, the following:

  1. The pathogenic mechanisms by which circulatory and coagulation system dysfunctions exacerbate infectious diseases;
  2. The role of endothelial cells and platelets in the immunological response to infections;
  3. Advances in diagnostic techniques for detecting circulatory and coagulation anomalies in the context of infectious diseases;
  4. The potential of anticoagulant therapies in the management of infection-related complications.

We welcome original research articles and comprehensive review papers that provide insights into the molecular and cellular aspects of this topic.

Prof. Dr. Hsin-Hou Chang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • infectious diseases
  • circulatory dysfunction
  • coagulation disorders
  • endothelial activation
  • platelet aggregation
  • anticoagulant therapy
  • diagnostic biomarkers
  • therapeutic targets

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Published Papers (1 paper)

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Research

14 pages, 3787 KiB  
Article
Distinct Hemostasis and Blood Composition in Spiny Mouse Acomys cahirinus
by Nikita S. Filatov, Rafael R. Khismatullin, Airat I. Bilyalov, Alina I. Khabirova, Shakhnoza M. Salyakhutdinova, Roman V. Ursan, Roza N. Kasimova, Alina D. Peshkova, Insaf I. Gazizov, Elena I. Shagimardanova, Mary V. Woroncow, Andrey P. Kiyasov, Rustem I. Litvinov and Oleg A. Gusev
Int. J. Mol. Sci. 2024, 25(23), 12867; https://doi.org/10.3390/ijms252312867 (registering DOI) - 29 Nov 2024
Abstract
The spiny mouse (Acomys species) is capable of scarless wound regeneration through largely yet unknown mechanisms. To investigate whether this capacity is related to peculiarities of the hemostatic system, we studied the blood of Acomys cahirinus in comparison to Mus musculus (Balb/c) [...] Read more.
The spiny mouse (Acomys species) is capable of scarless wound regeneration through largely yet unknown mechanisms. To investigate whether this capacity is related to peculiarities of the hemostatic system, we studied the blood of Acomys cahirinus in comparison to Mus musculus (Balb/c) to reveal differences in blood composition and clotting in both males and females. In response to surgical manipulations, blood clots formed in wounds of Acomys comprised a stronger hemostatic seal with reduced surgical bleeding in comparison with Balb/c. Acomys demonstrated notably shorter tail bleeding times and elevated clottable fibrinogen levels. Histological analysis revealed that clots from Acomys blood had densely packed fibrin-rich clots with pronounced fibrin segregation from erythrocytes. Acomys exhibited superior plasma clot stiffness as revealed with thromboelastography. The latter two characteristics are likely due to hyperfibrinogenemia. Light transmission platelet aggregometry demonstrated that ADP-induced platelet aggregates in Acomys males are stable, unlike the aggregates formed in the plasma of Balb/c undergoing progressive disaggregation over time. There were no apparent distinctions in platelet contractility and baseline expression of phosphatidylserine. Hematological profiling revealed a reduced erythrocytes count but increased mean corpuscular volume and hemoglobin content in Acomys. These results demonstrate the distinctive hemostatic potential of Acomys cahirinus, which may contribute to their remarkable regenerative capacity. Full article
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