How Melanin Affects the Therapy Response of Cutaneous Melanoma?
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 877
Special Issue Editor
Interests: tumor microenvironment; extracellular acidosis; tumor angiogenesis; tumor-derived extracellular vescicles (exososmes-ectososmes); cancer metabolism
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Special Issue Information
Dear Colleagues,
Great advances have been achieved in the treatment of cutaneous melanoma, especially with the introduction of immunotherapy. In spite of this, the cure for advanced melanoma still represents a huge challenge for clinicians. If not diagnosed early and surgically resected, cutaneous melanoma metastasizes very rapidly indeed, and the occurrence of therapy resistance worsens patients’ outcomes. Much effort has been made by the scientific community to understand the molecular mechanisms leading to melanoma resistance and to develop new targets and thereby new potential therapeutic approaches for advanced melanoma patients. Clinical evidence suggests that melanin synthesis can affect the therapy response of cutaneous melanoma patients. Although amelanotic lesions are more difficult to diagnose than melanotic melanomas, clinical and experimental evidence show that hyperpigmented melanomas are actually more resistant to radio-, chemo-, immuno-, and targeted therapies. The comprehension of the mechanisms involved in such interactions can lead to the identification of potential therapeutic targets and new clinical approaches for resistant melanoma patients. Thereby, for this Special Issue, research articles, we welcome short communications and systematic reviews that represent significant contributions to this topic.
Dr. Elena Andreucci
Guest Editor
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Keywords
- cutaneous melanoma
- melanin
- hyperpigmentation
- tyrosinase
- therapy resistance
- molecular medicine
- new therapeutic targets
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