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Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 6180

Special Issue Editors

Dr. Antonio Carrillo-Vico

E-Mail Website1 Website2
Guest Editor
1. Institute of Biomedicine of Seville (IBiS), University of Seville, CSIC, 41013 Sevilla, Spain
2. Department of Medical Biochemistry and Molecular Biology, University of Seville, 41013 Sevilla, Spain
Interests: bioactive compounds; immunomodulation; oxidative stress; melatonin; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Dr. Ivan Cruz-Chamorro

E-Mail Website
Guest Editor
Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain
Interests: functional foods; protein hydrolysate; antioxidant; immunomodulation; natural extracts; biopeptides; lupine; hemp; olive
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last two decades, plant bioactive compounds have been reported to confer beneficial health effects, such as antioxidant, anti-inflammatory, anti-cancer, anti-hypertensive, hypoglycemic, lipid-lowering, and metabolic effects, among others.

All these effects were described from in vitro and in vivo studies in which different plant-derived compounds, including proteins, protein hydrolysates, specific peptides, polyphenols, oils, juices, flowers, seeds, etc., were used.

Currently, there is a big increase in modern society lifestyle-related diseases, which are characterized by the loss of control of the antioxidant and immune systems, as well as metabolic processes. Thus, plant bioactive compounds that are capable of modifying or controlling these factors could be suitable candidates to develop plant-based functional food in health promotion.

It is also noteworthy the increasing attention to the environmental impact of the modern animal agriculture. Thus, the identification bioactive compounds from natural vegetable sources is an interesting strategy not only for replacing animal proteins with plant proteins, which is a central issue for health, but also for reducing the environmental impact of animal agriculture.

Therefore, this Special Issue of International Journal of Molecular Sciences, entitled “Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0”, welcomes the submission of original articles or reviews that can improve the knowledge about the beneficial health effects of vegetable compounds, such as immunomodulation, antioxidant, and metabolic regulation.

Dr. Antonio Carrillo-Vico
Dr. Ivan Cruz-Chamorro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • inflammation
  • metabolism
  • plant bioactive compounds
  • functional food
  • nutraceuticals
  • natural extracts
  • human health
  • nutrition
  • metabolic syndrome
  • chronic diseases
  • cardiovascular diseases
  • cancer

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Published Papers (5 papers)

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Research

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17 pages, 35306 KiB  
Article
Replacing Hydrolyzed Soybean Meal with Recombinant β-Glucosidase Enhances Resistance to Clostridium perfringens in Broilers Through Immune Modulation
by Jingxi Huang, Qihang Hou and Ying Yang
Int. J. Mol. Sci. 2024, 25(21), 11700; https://doi.org/10.3390/ijms252111700 - 31 Oct 2024
Viewed by 524
Abstract
Aglycone soy isoflavones have notable immune-regulatory bioactivity, while glycosidic forms in soybean meal pose challenges for absorption. β-Glucosidase (EC 3.2.1.21) catalyzes the non-reducing terminal β-d-glucosidic bonds, releasing β-d-glucan and aglycones. This study evaluated the impact of enzymatically hydrolyzed soybean [...] Read more.
Aglycone soy isoflavones have notable immune-regulatory bioactivity, while glycosidic forms in soybean meal pose challenges for absorption. β-Glucosidase (EC 3.2.1.21) catalyzes the non-reducing terminal β-d-glucosidic bonds, releasing β-d-glucan and aglycones. This study evaluated the impact of enzymatically hydrolyzed soybean meal (ESM) using recombinant β-glucosidase from Aspergillus niger on the growth performance and intestinal immune function of broilers under Clostridium perfringens infection. Prior to the feeding trial, soybean meal was enzymatically digested with recombinant β-glucosidase, ensuring almost complete conversion of glycosides to aglycones. After a week of pre-feeding, a total 180 healthy AA broilers were randomly assigned to three groups—control, semi-replacement of ESM (50% ESM), and full-replacement of ESM (100% ESM)—with 6 replicates of 10 chickens, and the trial lasted 28 days. On the 36th day, broilers were challenged with 1 mL of 1 × 1010 CFU/mL Clostridium perfringens (Cp) via gavage for 3 days. The results showed that the substitution of ESM had no effect on the body weight gain of broilers but significantly reduced the feed consumption and feed-to-gain ratio (p < 0.01). The study revealed that Cp significantly disrupted jejunal morphology, while ESM significantly mitigated this damage (p < 0.05). Real-time PCR results demonstrated that compared to the Cp group, ESM restored Cp-induced intestinal barrier impairments (e.g., Occludin, Claudin-1, Muc2), normalized aberrant cellular proliferation (PCNA) and apoptosis (Caspase-1 and Caspase-3), and upregulated the expression of anti-inflammatory factor Il-10 while suppressing pro-inflammatory cytokines (Il-1β, Il-6, and Il-8) (p < 0.05). Moreover, flow cytometry analyses demonstrated that ESM promoted Treg cell-derived Il-10, which alleviated macrophage-derived inflammation. Substituting conventional soybean meal with β-glucosidase, enzymatically treated, significantly reduced feed consumption and alleviated the intestinal damage and immune dysfunctions induced by Clostridium perfringens infection in broilers. Full article
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)
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16 pages, 3492 KiB  
Article
Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells
by Iwona Radziejewska, Katarzyna Supruniuk, Katarzyna Jakimiuk, Michał Tomczyk, Anna Bielawska and Anna Galicka
Int. J. Mol. Sci. 2023, 24(17), 13036; https://doi.org/10.3390/ijms241713036 - 22 Aug 2023
Cited by 1 | Viewed by 1712
Abstract
Specific changes in mucin-type O-glycosylation are common for many cancers, including gastric ones. The most typical alterations include incomplete synthesis of glycan structures, enhanced expression of truncated O-glycans (Tn, T antigens and their sialylated forms), and overexpression of fucosylation. Such altered glycans influence [...] Read more.
Specific changes in mucin-type O-glycosylation are common for many cancers, including gastric ones. The most typical alterations include incomplete synthesis of glycan structures, enhanced expression of truncated O-glycans (Tn, T antigens and their sialylated forms), and overexpression of fucosylation. Such altered glycans influence many cellular activities promoting cancer development. Tiliroside is a glycosidic dietary flavonoid with pharmacological properties, including anti-cancer. In this study, we aim to assess the effect of the combined action of anti-MUC1 and tiliroside on some cancer-related factors in AGS gastric cancer cells. Cancer cells were treated with 40, 80, and 160 µM tiliroside, 5 µg/mL anti-MUC1, and flavonoid together with mAb. Real-Time PCR, ELISA, and Western blotting were applied to examine MUC1 expression, specific, tumor-associated antigens, enzymes taking part in their formation, Gal-3, Akt, and NF-κB. MUC1 expression was significantly reduced by mAb action. The combined action of anti-MUC1 and tiliroside was more effective in comparison with monotherapy in the case of C1GalT1, ST3GalT1, FUT4, Gal-3, NF-κB, Akt mRNAs, and Tn antigen, as well as sialyl T antigen expression. The results of our study indicate that applied combined therapy may be a promising anti-gastric cancer strategy. Full article
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)
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20 pages, 4255 KiB  
Article
Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases
by Ana Abraão, Carlos Martins-Gomes, Raúl Domínguez-Perles, Ana Barros and Amélia M. Silva
Int. J. Mol. Sci. 2023, 24(10), 8830; https://doi.org/10.3390/ijms24108830 - 16 May 2023
Cited by 1 | Viewed by 1812
Abstract
Prunus lusitanica L. is a shrub belonging to the genus Prunus L. (Rosaceae family) that produces small fruits with none known application. Thus, the aim of this study was to determine the phenolic profile and some health-promoting activities of hydroethanolic (HE) extracts obtained [...] Read more.
Prunus lusitanica L. is a shrub belonging to the genus Prunus L. (Rosaceae family) that produces small fruits with none known application. Thus, the aim of this study was to determine the phenolic profile and some health-promoting activities of hydroethanolic (HE) extracts obtained from P. lusitanica fruits, harvested from three different locations. Qualitative and quantitative analysis of extracts was performed using HPLC/DAD-ESI-MS and antioxidant activity was assessed by in vitro methods. Antiproliferative/cytotoxic activity was determined on Caco-2, HepG2, and RAW 264.7 cells, anti-inflammatory activity was assessed using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, and the antidiabetic, antiaging, and neurobiological action of extracts was determined in vitro by assessing their inhibitory effect against the activity of α-amylase, α-glucosidase, elastase, tyrosinase, and acetylcholinesterase (AChE). Results showed that P. lusitanica fruit HE extracts from the three different locations showed identical phytochemical profile and bioactivities, although small differences were observed regarding the quantities of some compounds. Extracts of P. lusitanica fruits contain high levels in total phenolic compounds, namely, hydroxycinnamic acids, as well as flavan-3-ols and anthocyanins, primarily cyanidin-3-(6-trans-p-coumaroyl)glucoside. P. lusitanica fruit extracts have a low cytotoxic/antiproliferative effect, with the lowest IC50 value obtained in HepG2 cells (352.6 ± 10.0 μg/mL, at 48 h exposure), but high anti-inflammatory activity (50–60% NO release inhibition, at 100 μg/mL extract) and neuroprotective potential (35–39% AChE inhibition, at 1 mg/mL), and moderate antiaging (9–15% tyrosinase inhibition, at 1 mg/mL) and antidiabetic (9–15% α-glucosidase inhibition, at 1 mg/mL) effects. The bioactive molecules present in the fruits of P. lusitanica deserve to be further explored for the development of new drugs of interest to the pharmaceutical and cosmetic industry. Full article
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)
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Review

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24 pages, 892 KiB  
Review
Multifaced Nature of Yohimbine—A Promising Therapeutic Potential or a Risk?
by Agnieszka Nowacka, Martyna Śniegocka, Maciej Śniegocki, Ewa Ziółkowska, Dominika Bożiłow and Wojciech Smuczyński
Int. J. Mol. Sci. 2024, 25(23), 12856; https://doi.org/10.3390/ijms252312856 - 29 Nov 2024
Viewed by 210
Abstract
A natural compound derived from the Pausinystalia yohimbe tree—yohimbine, has a rich history of use in traditional medicine and is currently being explored for its potential therapeutic applications. This indole alkaloid primarily acts as an antagonist of α2-adrenergic receptors. Initially recognized for its [...] Read more.
A natural compound derived from the Pausinystalia yohimbe tree—yohimbine, has a rich history of use in traditional medicine and is currently being explored for its potential therapeutic applications. This indole alkaloid primarily acts as an antagonist of α2-adrenergic receptors. Initially recognized for its purported aphrodisiac properties, yohimbine has been investigated for a wide range of applications, including sports or the treatment of erectile dysfunction and metabolic disorders. However, toxicological concerns exist, particularly at higher doses. Ongoing researches help to fully assess yohimbine’s efficacy and safety profile and to explore strategies for enhancing its bioavailability and reducing toxicity. This review examines the multifaceted nature of yohimbine, delving into both its promising therapeutic potential and the associated risks. Full article
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)
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15 pages, 948 KiB  
Review
Rosmarinic Acid: A Potential Therapeutic Agent in Gastrointestinal Cancer Management—A Review
by Karolina Czerwińska and Iwona Radziejewska
Int. J. Mol. Sci. 2024, 25(21), 11704; https://doi.org/10.3390/ijms252111704 - 31 Oct 2024
Viewed by 629
Abstract
Gastrointestinal cancers are still the leading cause of death worldwide. This is related, among other things, to the non-specific symptoms, especially in the initial stages, and also to the limited possibilities for treatment. Therefore, research is still being conducted to improve the detection [...] Read more.
Gastrointestinal cancers are still the leading cause of death worldwide. This is related, among other things, to the non-specific symptoms, especially in the initial stages, and also to the limited possibilities for treatment. Therefore, research is still being conducted to improve the detection of this type of cancer and increase the effectiveness of therapy. The potential application of natural compounds in cancer management deserves special attention. In the group of such products, there are polyphenolic compounds that reveal, e.g., anti-oxidative, anti-carcinogenic, anti-inflammatory, anti-diabetic, and neuroprotective properties. One of these polyphenols is rosmarinic acid, commonly found in plants such as the Boraginaceae and Nepetoideae subfamilies of the Lamiaceae (mint) family. A number of studies have considered the positive effects of rosmarinic acid in the treatment of many cancers, including gastrointestinal ones such as oral, stomach, pancreas, colon, and liver cancers. The main aim of this paper was to summarize the mechanisms of action of rosmarinic acid in gastrointestinal cancers. Full article
(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)
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